Results 41 to 50 of about 1,418,376 (272)

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Kometni preskus v modelni prehranski raziskavi

Acta Agriculturae Slovenica, 2000
Prehrana je pomembno povezana z nastajanjem prostih radikalov v organizmu in zaščito pred njimi. Tako na primer večkrat nenasičene maščobne kisline povečujejo obremenitev organizma s prostimi radikali. Antioksidativne snovi proste radikale nevtralizirajo.
Romana MARINŠEK-LOGAR, Tanja PAJK, Karl SALOBIR   +2 more
doaj   +1 more source

Effects of T- and P-odd weak nucleon interaction in nuclei: renormalizations due to residual strong interaction, matrix elements between compound states and their correlations with P-violating matrix elements

, 1994
Manifestations of P-,T-odd weak interaction between nucleons in nucleus are considered. Renormalization of this interaction due to residual strong interaction is studied.
A. Barroso, A. Bohr, A. Griffiths, A. Schafer, A.B. Migdal, C.M. Frankle, D. Boose, D. Cho, D.F. Zaretsky, D.F. Zaretsky, E. Blanke, E.M. Henley, F. Osterfeld, G. Adelberger, G. Bertsch, G.A. Lobov, G.E. Brown, I.B. Khriplovich, I.S. Towner, J. Speth, J.B. French, J.D. Bowman, J.F. Shriner, Jr., J.W. Negele, K. Goeke, L. Stodolsky, L.D. Landau, L.V. Inzhechik, L.V. Inzhechik, N. Auerbach, O. K. Vorov, O.P. Sushkov, O.P. Sushkov, O.P. Sushkov, P.A. Moldauer, P.K. Kabir, R. De Haro, S.G. Kadmensky, S.G. Kadmensky, S.K. Lamoreax, V. Klemt, V. V. Flambaum, V.A. Khodel, V.E. Bunakov, V.F. Dmitriev, V.M. Khatsymovsky, V.V. Flambaum, V.V. Flambaum, V.V. Flambaum, V.V. Flambaum, V.V. Flambaum, V.V. Flambaum, V.V. Flambaum, V.V. Flambaum, W.C. Haxton, Ya.B. Zeldovich   +55 more
core   +1 more source

Parity nonconservation effects in the photodesintegration of polarized deuterons [PDF]

, 2002
P-odd correlations in the deuteron photodesintegration are considered. The $\pi$-meson exchange is not operative in the case of unpolarized deuterons. For polarized deuterons a P-odd correlation due to the $\pi$-meson exchange is about $3 \times 10^{-9}$.
A. I. Mikhailov, B. Desplanques, B. Desplanques, C. S. Woods, D. Tadić, E. Adelberger, F. Partovi, G. S. Danilov, G. S. Danilov, H. C. Lee, I. B. Khriplovich, I. B. Khriplovich, J. P. Leroy, K. R. Lassey, M. Gari, M. Porrmann, R. J. Blin-Stoyle, R. V. Korkin, T. Oka, V. B. Berestetskii, V. V. Flambaum, V. V. Flambaum, V. V. Flambaum, W. Y. P. Hwang, W. Y. P. Hwang   +24 more
core   +3 more sources

Applicability of mitotic figure counting by deep learning: a development and pan‐cancer validation study

FEBS Open Bio, EarlyView.
In this study, we developed a deep learning method for mitotic figure counting in H&E‐stained whole‐slide images and evaluated its prognostic impact in 13 external validation cohorts from seven different cancer types. Patients with more mitotic figures per mm2 had significantly worse patient outcome in all the studied cancer types except colorectal ...
Joakim Kalsnes, Maria X. Isaksen, Frida Julbø, Manohar Pradhan, Andreas Kleppe, Sepp De Raedt, Ole‐Johan Skrede, Turid Torheim, John Arne Nesheim, Hans Martin Mohn, Hanne A. Askautrud, Karolina Cyll, Wanja Kildal, Emma Rewcastle, Melinda Lillesand, Vebjørn Kvikstad, Emiel Janssen, Robert Jones, Odd Terje Brustugun, Bjørn Brennhovd, Erik Skaaheim Haug, Lill‐Tove Rasmussen Busund, Elin Richardsen, Sigve Andersen, Tom Dønnem, Kristina Lindemann, Gunnar Kristensen, Neil A. Shepherd, Marco Novelli, Knut Liestøl, David Kerr, Håvard E. Danielsen, Tarjei S. Hveem   +32 more
wiley   +1 more source

Genetske razlike med istrsko pramenko, bovško ovco in jezersko-solčavsko ovco

Acta Agriculturae Slovenica, 2002
Z namenom, da bi ocenili genetsko sorodnost med tremi slovenskimi avtohtonimi pasmami ovc smo proučevali razlike na mikrosatelitnih lokusih: MAF214, OarCP49, OarFCB11, MAF65, McM42, TGLA53, McM527 in OarAE119.
Tatjana KAVAR, Drago KOMPAN, Peter DOVČ
doaj   +1 more source

Observed parity-odd CMB temperature bispectrum

, 2015
Parity-odd non-Gaussianities create a variety of temperature bispectra in the cosmic microwave background (CMB), defined in the domain: $\ell_1 + \ell_2 + \ell_3 = {\rm odd}$.
Fergusson, James R., Liguori, Michele, Shiraishi, Maresuke   +2 more
core   +1 more source

New Onset of Fibromyalgia After Exposure to a Combat Environment: A Longitudinal Cohort Study

Arthritis Care &Research, EarlyView.
Objective Traumatic life events are hypothesized to be triggers for the onset of fibromyalgia. Posttraumatic stress disorder (PTSD) is a common comorbidity of fibromyalgia. However, limited prospective data are available on the development of fibromyalgia after exposure to high‐magnitude stress.
Jay B. Higgs, Willie J. Hale, Casey L. Straud, Jim Mintz, Stacey Young‐McCaughan, Kimberly D. Gomes, Chelsea J. Sterne, Katrina M. Lawrence‐Wolff, Alan J. Bartholomew, Kevin M. Kelly, Douglas M. Maurer, Catherine Vriend, Brett T. Litz, Douglas E. Williamson, Alan L. Peterson, for the STRONG STAR Consortium   +15 more
wiley   +1 more source

Competition between isoscalar and isovector pairing correlations in N=Z nuclei

, 2004
We study the isoscalar (T=0) and isovector (T=1) pairing correlations in N=Z nuclei. They are estimated from the double difference of binding energies for odd-odd N=Z nuclei and the odd-even mass difference for the neighboring odd-mass nuclei ...
K. Kaneko, K. Kaneko, M. Hasegawa
core   +1 more source

Prospects of Electric Field Control in Perpendicular Magnetic Tunnel Junctions and Emerging 2D Spintronics for Ultralow Energy Memory and Logic Devices

Advanced Functional Materials, EarlyView.
Electric control of magnetic tunnel junctions offers a path to drastically reduce the energy requirements of the device. Electric field control of magnetization can be realized in a multitude of ways. These mechanisms can be integrated into existing spintronic devices to further reduce the operational energy.
Will Echtenkamp, Brahmdutta Dixit, Yifei Yang, Deyuan Lyu, Thomas Peterson, Qi Jia, Yu‐Chia Chen, Jian‐Ping Wang   +7 more
wiley   +1 more source