Results 171 to 180 of about 1,571,635 (343)

METTL10‐Mediated PIAS3 Methylation Links Purine Metabolism to Gastric Cancer Progression

open access: yesAdvanced Science, EarlyView.
METTL10‐mediated methylation of PIAS3 at K442 inhibits its SUMO E3 ligase activity toward MITF. This reduces MITF SUMOylation and subsequent RNF4‐mediated ubiquitination, leading to MITF protein accumulation and gastric cancer progression. Abstract Metabolic dysregulation plays a significant role in the development of gastric cancer (GC).
Jinshui Tan   +20 more
wiley   +1 more source

Hepatic CBP/p300 Orchestrate Amino Acid‐Driven Gluconeogenesis through Histone Crotonylation

open access: yesAdvanced Science, EarlyView.
Hepatic CBP/p300 control amino acid‐driven gluconeogenesis by modulating histone crotonylation. This study identifies 2‐aminoadipate (2‐AAA) as a key metabolite that enhances crotonylation and activates amino acid and gluconeogenic gene expression.
Chunxiang Sheng   +15 more
wiley   +1 more source

Homocysteine Exacerbates Pulmonary Fibrosis via Orchestrating Syntaxin 17 Homocysteinylation of Alveolar Type II Cells

open access: yesAdvanced Science, EarlyView.
The study identifies elevated homocysteine (Hcy) levels in idiopathic pulmonary fibrosis patients' samples, with alveolar type 2 cells as the primary site of Hcy metabolism. Methionine synthase reductase downregulation in these cells exacerbates fibrosis, while folate administration reduces Hcy levels and alleviates fibrosis.
Jiefeng Huang   +14 more
wiley   +1 more source

CONSERVATIVE TENDENCY OF THE CRUDE ODDS RATIO

open access: bronze, 2001
Masayuki Doi   +2 more
openalex   +2 more sources

The reporting odds ratio versus the proportional reporting ratio: ‘deuce’ [PDF]

open access: green, 2004
Patrick Waller   +3 more
openalex   +1 more source

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