Results 181 to 190 of about 15,072 (248)

Metabolite‐sensitive cross‐bridge models of human atria reveal the impact of diabetes on muscle mechanoenergetics

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend In this study, we used mathematical modelling to explore the effect of diabetes on muscle mechanoenergetics. Our parameterisation of cross‐bridge models using data from non‐diabetic and diabetic human atrial tissues revealed lower values for cross‐bridge stiffness, detachment rates, attachment rates and lower ATP sensitivity in ...
Julia H. Musgrave   +4 more
wiley   +1 more source

Computational modelling of cardiac fibroblast signalling reveals a key role for Ca2+ in driving atrial fibrillation‐associated fibrosis

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend A pre‐existing fibroblast signalling model was enhanced by integrating atrial‐specific components and reactions linked to atrial fibrosis and atrial fibrillation (AF). The analysis highlights the central role of Ca2⁺ signalling in driving profibrotic responses to AF‐relevant stimuli, angiotensin‐II and transforming growth factor ...
Najme Khorasani   +5 more
wiley   +1 more source

A computational model for retinal haemodynamics under gravitational and postural variations

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend The haemodynamic impact of gravitational and postural changes on the retina, and its relevance to spaceflight associated neuro‐ocular syndrome (SANS), remains incompletely characterized. This study assesses retinal haemodynamics from upright to head‐down tilt using a lumped‐parameter model that dynamically couples intraocular ...
Michele Nigro   +2 more
wiley   +1 more source

Sarcolemmal and mitochondrial membrane potentials measured ex vivo and in vivo in the heart by pharmacokinetic modelling of [99mTc]sestamibi

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend The pharmacokinetics of lipophilic cationic radiotracers such as [99mTc]sestamibi and [99mTc]tetrofosmin are dependent on the electrical potentials that determine their distribution across the sarcolemmal and mitochondrial membranes.
Edward C. T. Waters   +5 more
wiley   +1 more source

A priori bounds for the generalised parabolic Anderson model

open access: yesCommunications on Pure and Applied Mathematics, Volume 79, Issue 5, Page 1315-1394, May 2026.
Abstract We show a priori bounds for solutions to (∂t−Δ)u=σ(u)ξ$(\partial _t - \Delta) u = \sigma (u) \xi$ in finite volume in the framework of Hairer's Regularity Structures [Invent Math 198:269–504, 2014]. We assume σ∈Cb2(R)$\sigma \in C_b^2 (\mathbb {R})$ and that ξ$\xi$ is of negative Hölder regularity of order −1−κ$- 1 - \kappa$ where κ<κ¯$\kappa <
Ajay Chandra   +2 more
wiley   +1 more source

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