Results 181 to 190 of about 37,826 (288)

QSP Modeling Shows Pathological Synergism Between Insulin Resistance and Amyloid‐Beta Exposure in Upregulating VCAM1 Expression at the BBB Endothelium

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 561-571, March 2025.
ABSTRACT Type 2 diabetes mellitus (T2DM), characterized by insulin resistance, is closely associated with Alzheimer's disease (AD). Cerebrovascular dysfunction is manifested in both T2DM and AD, and is often considered as a pathological link between the two diseases.
Zengtao Wang, Vaishnavi Veerareddy, Xiaojiao Tang, Kevin J. Thompson, Sunil Krishnan, Krishna R. Kalari, Karunya K. Kandimalla   +6 more
wiley   +1 more source

Implementing physics-informed neural networks with deep learning for differential equations. [PDF]

Front Artif Intell
Emmert-Streib F, Tripathi S, Farea A, Holzinger A.   +3 more
europepmc   +1 more source

A Multiple‐Model‐Informed Drug‐Development Approach for Optimal Regimen Selection of an Oncolytic Virus in Combination With Pembrolizumab

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 572-582, March 2025.
ABSTRACT The antitumor efficacy of an intratumoral injection of a genetically engineered oncolytic vaccinia virus carrying human IL‐7 and murine IL‐12 genes (hIL‐7/mIL‐12‐VV) was demonstrated in CT26.WT‐bearing mice. In the CT26.WT‐bearing mouse model, the efficacy of the combination of hIL‐7/mIL‐12‐VV plus the anti‐programmed cell death protein (PD)‐1
Akihiro Yamada, Mary P. Choules, Frances A. Brightman, Shigeru Takeshita, Shinsuke Nakao, Nobuaki Amino, Takeshi Nakayama, Masato Takeuchi, Kanji Komatsu, Fernando Ortega, Hitesh Mistry, David Orrell, Christophe Chassagnole, Peter L. Bonate   +13 more
wiley   +1 more source

The evolution of nonlinear mixed effects modeling in pharmacometrics: toward AI-based variational autoencoders. [PDF]

J Pharmacokinet Pharmacodyn
Rohleff J, Koch G, Schropp J.
europepmc   +1 more source

Stratospheric influence on tropical cyclone evolution

Quarterly Journal of the Royal Meteorological Society, EarlyView.
We developed a metric based on moist static energy to detect and quantify the intrusion of stratospheric air into the inner core of tropical cyclones. High‐resolution numerical simulations show that this stratospheric interaction forms warm anomalies (high‐level warm cores) in the upper troposphere.
Andrea Davin, Giousef Alexandros Charinti, Caroline Muller, Andrea Polesello, Claudia Pasquero   +4 more
wiley   +1 more source

Odorant degrading enzyme candidates enriched in the antennae of the white-spotted flower chafer, <i>Protaetia brevitarsis</i>. [PDF]

Front Insect Sci
Lu Y, Gao P, Wang X, Yuan J, Zhang H, Zhang J.   +5 more
europepmc   +1 more source

Spectral Submanifolds of Delay Systems: Control in Continuous and Discrete Time

International Journal of Robust and Nonlinear Control, EarlyView.
ABSTRACT This paper presents both continuous‐time and discretization‐based approaches for constructing spectral submanifolds (SSMs) for time delay systems. The continuous‐time approach built upon sun–star calculus, reformulates the governing delay differential equation (DDE) as an operator differential equation (OpDE).
Bence Szaksz, Gábor Orosz, Gábor Stépán   +2 more
wiley   +1 more source

HySimODE: a hybrid stochastic-deterministic simulation framework for multiscale models of biological systems. [PDF]

Bioinformatics
Zamora-Chimal CG, Darlington APS.
europepmc   +1 more source

Soldaten Ode

, 2012
Source: Sidonia Hedwig Zäunemann: Poetische Rosen in Knospen, Erfurt: Johann Heinrich Nonne, 1738.
openaire   +2 more sources

Stair‐Climbing Wheelchairs for Enhanced Mobility: A Comprehensive Review of Fundamental Mechanisms, Design Concepts, and Performance Analysis

Journal of Field Robotics, EarlyView.
ABSTRACT People with physical disabilities face significant mobility challenges while climbing uneven surfaces and staircases. In these circumstances, traditional wheelchairs do not provide stable, safely controlled mobility, underscoring the importance of building superior stair‐climbing wheelchairs for both medical and infrastructure purposes.
Gopisetti Manikanta, S. M. Abhinandan, Anand Reddy, G. Chandana, Divya, P. Anil Kumar, Ch. Venkata Rao, Ashish Garg, Ravi C. Soni, Jogendra Kumar, Bhargav Akkinepally   +10 more
wiley   +1 more source