Results 131 to 140 of about 98,650 (241)

IRIT-MFU Multi-modal systems for emotion classification for Odyssey 2024 challenge

International audienceIn this paper, we present our contribution to emotion classifi- cation in speech as part of our participation in Odyssey 2024 challenge.
Quintas, Sebastião, Benamara, Farah, Bertrand, Marie-Françoise, Pagés, Clément, Moudjari, Leila, Bredin, Hervé, Moriceau, Véronique, Lafore, Adrien, Pellegrini, Thomas, Farinas, Jérôme, Ferrané, Isabelle, Bertrand, Jérôme   +11 more
core   +1 more source

A covalent peptide engager approach to equip immunotherapeutic monoclonal and pan IgG serum antibodies with new tumour‐targeting function

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Site‐specific antibody modification is a useful chemical strategy to elaborate antibody therapeutic function. Conventional lysine‐ or cysteine‐based conjugation methods generate heterogeneous products, while protein engineering approaches are resource‐intensive.
Karolina Krygier, Sandra Szu‐Wei Hwang, Anthony F. Rullo   +2 more
wiley   +1 more source

SMARTCLOTH-Odyssey for Nutrition Education in Type 1 Diabetes: Development and Acceptability Study of a Gamified Web-Based Platform for Diabetes Nurse Educators Using a Human-Centered Design Approach. [PDF]

JMIR Diabetes
Molina-Recio G, Ariza-Jimenez AB, Membrillo-Del Pozo A, Zafrilla-Sanchez S, Alvarez-Moral J, Velez-Leon JL, Gonzalez-Illanes R, Molina-Luque R.   +7 more
europepmc   +1 more source

The c‐Src inhibitor eCF506 diminishes opioid tolerance and reduces β‐arrestin2 recruitment

British Journal of Pharmacology, EarlyView.
Morphine activation of μ receptors causes tolerance through c‐Src activation and β‐arrestin2 recruitment. c‐Src inhibition or degradation reduces β‐arrestin2 recruitment, μ receptor endocytosis, while causing receptor upregulation, all likely contributing to reduced morphine tolerance.
Samuel Singleton, Fraser Nunn, Erika Lace, Álvaro Lorente‐Macías, Rachel Toth, Asier Unciti‐Broceta, Tim G. Hales   +6 more
wiley   +1 more source

Deep Phenotyping in ReNU Syndrome Identifies a Recognizable Age‐Dependent Clinical Trajectory

Clinical Genetics, EarlyView.
Longitudinal evaluation of 11 individuals with ReNU syndrome revealed an age‐dependent multisystem trajectory. This longitudinal description may help clinicians anticipate changing needs in feeding, growth, neurological, visual, communication, behavioral, and orthopedic care. ABSTRACT Pathogenic variants in the noncoding gene RNU4‐2 cause ReNU syndrome,
Nadja Pekkola Pacheco, Malin Kvarnung, Anna Hammarsjö, Daniel Nilsson, Bianca Tesi, Britt Marie Anderlid, Giedre Grigelioniene, Maria Johansson Soller, Liselot van der Laan, Charlotte Willfors, Charlotta Ingvoldstad Malmgren, Anna Lindstrand, Tommy Stödberg, Ann Nordgren, Angelica Maria Delgado‐Vega   +14 more
wiley   +1 more source

Borderline Significance or Biological Signal? Reinterpreting the ODYSSEY-HCM Trial in Non-obstructive Hypertrophic Cardiomyopathy. [PDF]

Eur Cardiol
Prajapathi S, Mohta A, Shah B, Pradhan A.   +3 more
europepmc   +1 more source

Obtaining a Diagnostic Yield via Scan findings prior to the introduction of SEquencing retrospectivelY (ODYSSEY): a cohort study. [PDF]

Ultrasound Obstet Gynecol
Sonner S, Mckenna C, Flanagan C, Mckee S, Ververi A, Doyle S, Ong S, Mcknight AJ, Mone F.   +8 more
europepmc   +1 more source

Consensus definition for developmental regression during childhood

Developmental Medicine &Child Neurology, EarlyView.
In this study, 41 expert interdisciplinary clinicians participated in two rounds of a Delphi survey to reach a consensus agreement on the developmental domains and duration of regression. Reaching an agreed working definition is a crucial first step towards the earlier and consistent identification of children experiencing developmental regression ...
Gauravi Gawade, Ellaina P Andersson, Ava Nielsen, Katrina Williams, Kirsten Furley   +4 more
wiley   +1 more source

Predictors of Treatment Failure in Children With HIV Starting First-line Antiretroviral Therapy in the ODYSSEY Trial. [PDF]

Clin Infect Dis
Wyncoll J, Kamolrattana R, Archary M, Mujuru HA, Kekitiinwa AR, Violari A, Na-Rajsima S, Lugemwa A, Variava E, Cotton M, Kityo CM, Königs C, Behuhuma NO, Welch S, Saïdi Y, Marques L, Ahimbisibwe GM, Houlden L, Giaquinto C, Rojo P, Gibb DM, Puthanakit T, Turkova A, White E, Ford D, ODYSSEY Trial Team.   +25 more
europepmc   +1 more source

RCC1 neuropathy mimics childhood axonal Guillain–Barré syndrome with variable clinical severity and survival

Developmental Medicine &Child Neurology, EarlyView.
We present 10 patients who presented with acute onset axonal neuropathy following infection, mimicking childhood axonal Guillain–Barré syndrome. We review phenotypes, undertake survival analysis, and assess function of novel RCC1 variants in vitro. Abstract Aim To assess the phenotype and genotype of 10 new patients with biallelic RCC1 variants who ...
Han Zhang, Beril Din, John H. McDermott, RCC1 Neuropathy Study Group, Adam Jackson, Halil Tuna Akar, Ali Dursun, Riza Koksal‐Ozgul, Reza Sadjadi, Lauren Politica, Stephan Zuchner, Reza Maroofian, Usman Ali, Dudu Turkyilmaz, Jawadur Rahman, Hasan Bas, Khalid Hussain, Khalid A Fakhro, Aljazi Al‐Maraghi, Annemarie CS Knijnenburg, Monique Engel, Debby Hellebrekers, Heike Losch, Sietse M Aukema, Marlene Kullik, Christoph Geier, Raymond T. O'Keefe, William G. Newman, J. Robert Harkness   +28 more
wiley   +1 more source