Results 41 to 50 of about 443,504 (230)
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
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Gong-kuang zidonghuaCurrent simulation studies on the distribution pattern of magnetic flux leakage (MFL) in broken strands of wire ropes primarily use finite element static magnetic field simulation models. In these models, the wire rope and the damage detection instrument
WEI Mingjiang +4 more
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The Indian Journal of Agricultural Sciences, 2016 Studies on the effect of covering material on off-season cut flower production of chrysanthemum (Dendranthema grandiflora Tzvelev) were carried out at the experimental farm of the Department of Floriculture and Landscape Architecture, Dr Yashwant Singh ...
PALMSEY M SANGMA +3 more
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Applied Sciences, 2023 In order to effectively control the stability of surrounding rock in ultra-large span open-off cuts by employing the techniques of support strength theory calculations and analogical application methods, two sets of rational support schemes were proposed,
Lin Pu +4 more
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FEBS Letters, EarlyView.Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
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Optimizing Bus Rapid Transit Systems: A Simulation Approach to Scheduling
Journal of Advanced TransportationDriven by increasing urbanization and traffic congestion challenges, efficient and cost-effective public transportation solutions have become essential, positioning bus rapid transit (BRT) systems as an attractive alternative to conventional modes.
Safwan Altarazi, Nadia Janho
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Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
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Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
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Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
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FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
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