Results 71 to 80 of about 443,504 (230)

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

FEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara, Kinga Skoczek, Elzbieta Pyza, Milena Damulewicz   +3 more
wiley   +1 more source

A Dynamic Load Modulation Power Amplifier with Ferroelectric-Based Tunable Matching Network

Sensors
Power amplifiers are crucial components that significantly influence the linearity and energy efficiency of next-generation communication system radio units. A key challenge in designing power amplifiers is managing high peak-to-average power ratio (PAPR)
Pavel Turalchuk, Irina Filipiuk, Bayazet Iskakov   +2 more
doaj   +1 more source

Mixed‐class J‐domain protein scaffolds promote expanded aggregate handling and multivalent Hsp70 engagement during functional disaggregase assembly

FEBS Letters, EarlyView.
Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley   +1 more source

Regional Cooling and Peak-Load Performance of Naturally Ventilated Cavity Walls in Representative U.S. Climate Zones

Architecture
Naturally ventilated cavity walls (VCWs) retrofit conventional cavity walls with vents that enable buoyancy- or wind-driven airflow and reduce cooling loads during summer. When closed, they retain the thermal performance of traditional walls.
Ri Na, Abdulaziz Banawi, Behzad Abbasnejad   +2 more
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Systematic Design of a Compact Lumped-Element Outphasing Class-E Power Amplifier for HF Band

IEEE Access
This paper presents a novel design methodology for an outphasing Class-E power amplifier operating at 27.12 MHz, specifically addressing limitations inherent to traditional outphasing combiners that utilize distributed microstrip transmission lines for ...
Khairul Hilmi Yusof, Farid Zubir, Mohamad Kamal A. Rahim, Narendra Kumar, Jagadheswaran Rajendran, Noorlindawaty Md Jizat, Peter Gardner, Thomas Johnson   +7 more
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Design and implementation of a full analogue gate driver for current compensation of paralleled SiC‐MOSFETs

IET Power Electronics
Silicon carbide MOSFETs have current ratings that are not sufficiently high to be used in high‐power converters. It is necessary to connect several MOSFETs in parallel in order to increase current capabilities.
Adel Rezaeian, Ahmad Afifi, Hamid Bahrami   +2 more
doaj   +1 more source

Parametric Analysis and Optimization of Wire EDM for Improved Surface Roughness of D2 Tool Steel Using Response Surface Methodology

International Journal of Applied Mechanics and Engineering
This study presents a systematic investigation into the optimization of Wire Electrical Discharge Machining (WEDM) parameters for improving the surface finish of D2 tool steel.
Dipak Parasram Kharat, Mahendra P Nawathe   +1 more
doaj   +1 more source