Results 91 to 100 of about 5,507,855 (280)

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

open access: yesMolecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim   +11 more
wiley   +1 more source

Based on the Hardware Resources Configurable Shanke PLC Building Energy Consumption Detection System

open access: yesMATEC Web of Conferences, 2017
According to the actual situation of the comprehensive office building and the functional requirements of the building energy consumption monitoring and management system, the office building energy consumption monitoring and management system is ...
Cheng Guanghe   +4 more
doaj   +1 more source

Ohio State Office Building construction

open access: yes, 1931
Steel frame of the Ohio State Office Building in Columbus, Ohio, May 1, 1931. The groundbreaking for the Ohio State Office Building took place on November 19, 1929.

core  

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

open access: yesMolecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba   +5 more
wiley   +1 more source

Other Titles: Biennial Report of the Kansas State Office Building, 1960-1964 State Office Building (1960-1962) Executive Council--State Office Building (1964)

open access: yes, 1960
These biennial reports are summaries of the activities of this agency. They were extracted from a series of Kansas agency reports covering over 100 state agencies and institutions bound together for each biennium, 1959/1960 - 1979/1980. The Kansas State
Kansas. Executive Council.
core   +1 more source

Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy

open access: yesMolecular Oncology, EarlyView.
We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley   +1 more source

Energy and thermal modelling of an office building to develop an artificial neural networks model. [PDF]

open access: yesSci Rep, 2022
Santos-Herrero JM   +3 more
europepmc   +1 more source

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