Results 71 to 80 of about 2,560,195 (251)

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova   +25 more
wiley   +1 more source

Het kantoorgebouw van het electriciteitsgebouw te Rotterdam

open access: yesBulletin KNOB, 1990
The office building of the Municipal Electricity Service at Rotterdam is the first concrete working-out of the Dutch striving after multi-storey buildings and framed constructions in particular.
P. Kalsbeek
doaj   +1 more source

Can a naturally ventilated office outperform a mixed mode office? Pilot study on occupants' comfort [PDF]

open access: yes, 2018
It is established that a mixed mode indoor environment provides the best for occupant comfort by augmenting the passive system with a mechanical system when and where required.
Byrd, Hugh, Rasheed, Eziaku
core   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra   +6 more
wiley   +1 more source

Exploration of the Energy Efficiency of the Greater London Authority Building (GLA Building/City Hall)

open access: yesJournal of Applied Sciences and Environmental Management, 2010
This research paper set out to explore the following research question: “what shape and form should a building be in order to achieve energy efficiency in the design and construction of the tall office building?” This involved the exploratory case study ...
EE Osaji, J Hudson, P Chynoweth
doaj   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

open access: yesMolecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson   +9 more
wiley   +1 more source

Behaviour change at work: Empowering energy efficiency in the workplace through user-centred design [PDF]

open access: yes, 2011
Copyright @ 2011 University of California eScholarship RepositoryCO2 emissions from non-domestic buildings - primarily workplaces - make up 18 percent of the UK's carbon footprint.
Cain, R   +5 more
core   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

open access: yesMolecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos   +6 more
wiley   +1 more source

A heuristic tool for exposure reduction in indoor wireless networks [PDF]

open access: yes, 2012
A heuristic indoor network planner for exposure calculation and optimization in wireless networks is developed. The model for the electric-field strength in the vicinity of an access point is presented and the WiFi networks are optimized in order not to ...
Joseph, Wout   +3 more
core   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang   +12 more
wiley   +1 more source

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