Results 71 to 80 of about 5,968,774 (351)
FEBS Letters, EarlyView.Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson +7 more
wiley +1 more source
Structural biology of ferritin nanocages
FEBS Letters, EarlyView.Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley +1 more source
Behaviour change at work: Empowering energy efficiency in the workplace through user-centred design [PDF]
, 2011 Copyright @ 2011 University of California eScholarship RepositoryCO2 emissions from non-domestic buildings - primarily workplaces - make up 18 percent of the UK's carbon footprint.
Cain, R +5 more
core +1 more source
From Bentham to Guadet: ‘auditory visibility’ in nineteenth-century theories on government offices [PDF]
, 2019 Architectural historiography is seldom concerned with the antithetical notions of ‘noise’ and ‘silence’. In this case study, I tentatively explore the theme in the context of nineteenth-century administrative buildings.
Van de Maele, Jens
core +2 more sources
Linking human-building interactions in shared offices with personality traits [PDF]
, 2020 Occupant behavior influences office building energy performance. The level of human-building interactions (HBIs) in shared offices strongly influences building energy use and occupant well-being.
Chen, CF, Hong, T, Wang, Z, Xu, X
core +1 more source
Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells
FEBS Letters, EarlyView.Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López +2 more
wiley +1 more source
Twenty first century standards for thermal comfort : fostering low carbon building design and operation [PDF]
, 2010 Nearly 50% of energy consumed in the developed world is consumed in buildings. Despite regulation intent, many new buildings are energy profligate. Thermal comfort standards are partly responsible for this increase in consumption. In this volume, Roaf et
Boerstra, A. +4 more
core +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
Health and wellbeing in a deep plan office space [PDF]
, 2008 This research tracks public sector employees as they move from a 1960s office building into a purpose-built, environmentally sound, office accommodation.
Brown, Guy, Capper, Graham, Holmes, John
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