Results 91 to 100 of about 1,000,909 (309)

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Energy characterization of residential and office buildings in a tropical location. [PDF]

Heliyon, 2023
Cárdenas-Rangel J, Osma-Pinto G, Jaramillo-Ibarra J.   +2 more
europepmc   +1 more source

Behaviour change at work: Empowering energy efficiency in the workplace through user-centred design [PDF]

, 2011
Copyright @ 2011 University of California eScholarship RepositoryCO2 emissions from non-domestic buildings - primarily workplaces - make up 18 percent of the UK's carbon footprint.
Cain, R, Giudice, S, Harrison, DJ, Jennings, P, Lockton, D, Nicholson, L   +5 more
core   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

THERMAL COMFORT IN OFFICE BUILDINGS

Journal of Industrial Design and Engineering Graphics, 2019
In this paper is studied the thermal comfort in an office room. The first part of the paper presents the state of the art of numerical methods and graphical determination of the thermal comfort in buildings.
Ancuta Nadia Jurco, Liviu Iacob Scurtu
doaj   +4 more sources

Heat Stress Pattern in Conditioned Office Buildings with Shallow Plan Forms in Metropolitan Colombo

Buildings, 2019
This paper critically evaluates indoor overheating of multilevel office buildings in Colombo—a tropical warm humid city. The work questions the building morphological characteristics on thermal performance and indoor climate, thus the levels of ...
Upendra Rajapaksha
doaj   +1 more source

Thermal comfort and adaptive behaviors in office buildings: A pilot study in Turpan (China) during summer. [PDF]

Heliyon, 2023
Guo Y, Tang H, Gao Y, Wang Y, Meng X, Cai G, Zhao J, Dewancker BJ, Gao W.   +8 more
europepmc   +1 more source

Why are naturally ventilated office spaces not popular in New Zealand? [PDF]

, 2017
In this paper, we investigated the reason(s) why natural ventilation is not as popular as air-conditioned or mixed-mode ventilation systems in Green-rated office buildings in New Zealand. To achieve this, we had three objectives. Firstly, we reviewed the
Attmann, Baird, Blair Money, Brager, Brager, Byrd, Cole, Cole, De Dear, Eziaku Rasheed, Goncalves, Grady, Hugh Byrd, Jasper Mbachu, Kothari, Roaf, Roaf, Russell, Shove, Temtiope Egbelakin, Webb   +20 more
core   +2 more sources

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

The Potential Challenges and Limitations of Implementing Modern Office Design Features in Residential Spaces: A SPAR-4-SLR Approach

Buildings
The COVID-19 pandemic has significantly altered how people work, with an increasing number transitioning to working from home (WFH). This paradigm shift has raised various challenges in adapting living spaces to meet the needs of remote work.
James Olabode Bamidele Rotimi, Taofeeq Durojaye Moshood, Funmilayo Ebun Rotimi   +2 more
doaj   +1 more source