Results 71 to 80 of about 37,745 (263)

Building performance evaluation of an office building in the UK – a case study of a university office building [PDF]

, 2017
The efficiency of office building design has become increasingly important in recent years. This is both due to the negative impact inadequate office building design may have on the built environment due to excessive mechanical heating and cooling systems, as well as the impact of unsatisfactory thermal comfort and poor indoor thermal condition on the ...
Carter, Beth, Elsharkawy, Heba, Zahiri, Sahar   +2 more
openaire  

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Selected spatial effects of the global financial and economic crisis in Ljubljana, Slovenia [PDF]

Urbani Izziv, 2012
In 2007, the United States witnessed a financial crisis that gradually developed into one of the most serious global financial and economic recessions in the history of (post)modern society. Its effects are numerous.
Simon Kušar
doaj  

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

Stochastic and Distributed Optimal Energy Management of Active Distribution Networks Within Integrated Office Buildings

CSEE Journal of Power and Energy Systems
This paper proposes a stochastic and distributed optimal energy management approach for active distribution networks (ADNs) within office buildings.
Zening Li, Su Su, Xiaolong Jin, Mingchao Xia, Qifang Chen, Koji Yamashita   +5 more
doaj   +1 more source

Research on the application of distributed photovoltaic-battery systems in commercial-office complexes: The impact of building hybrid characteristics on PVB systems [PDF]

E3S Web of Conferences
The feasibility of distributed photovoltaic battery (PVB) systems in buildings has been validated, demonstrating that the integration of renewable energy with energy storage is essential for achieving low- carbon operational goals in buildings.
Wang Jingrong, Li Xiaofeng
doaj   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Seismic Risk Analysis of Government Buildings in the City of Tembilahan using FEMA P-58

Rekayasa Sipil
Research in estimating losses and harm experienced by structures in the high seismic zone had been conducted in previous studies. Yet there is limited study carried out in low-moderate seismic areas.
Rofriantona, Ridwan, Zulfikar Djauhari
doaj   +1 more source