Results 91 to 100 of about 3,391,201 (348)
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
Global Buildings Performance Network (GBPN) [PDF]
, 2015 The GBPN’s goal is to contribute to the building sector achieving its full energy savings and CO2mitigation potential of more than 2.1 Gt by 2030. The GBPN was founded in 2010 with the mandate to advance knowledge and expertise globally on building ...
Global Buildings Performance Network
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FEBS Letters, EarlyView.The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson +6 more
wiley +1 more source
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Environments, 2019 About half of the energy loss in buildings is wasted through windows. Determining the optimum window-to-wall ratio (WWR) for different building facades would reduce such energy losses.
J. Shaeri +3 more
semanticscholar +1 more source
FEBS Letters, EarlyView.Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley +1 more source
Energy performance regulations and methodologies of energy saving in office buildings in Southern Europe [PDF]
, 2009 This thesis was submitted for the degree of Master of Philosophy and awarded by Brunel University.The Directive 2002/91/EC of the European Parliament and Council on energy performance of buildings entered into force on 4th January 2003, setting the ...
Tsave, Anna A
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Life-cycle assessment of buildings: a Review [PDF]
, 2009 Life-Cycle Assessment (LCA) is one of various management tools for evaluating environmental concerns. This paper reviews LCA from a buildings perspective.
Menzies, Gillian Frances +5 more
core +1 more source
Building performance evaluation of an office building in the UK – a case study of a university office building [PDF]
, 2017 The efficiency of office building design has become increasingly important in recent years. This is both due to the negative impact inadequate office building design may have on the built environment due to excessive mechanical heating and cooling systems, as well as the impact of unsatisfactory thermal comfort and poor indoor thermal condition on the ...
Carter, Beth +2 more
openaire
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source