Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
The Effects of Ventilation and Filtration on Indoor PM<sub>2.5</sub> in Office Buildings in Four Countries. [PDF]
Build Environ, 2021 Jones ER +6 more
europepmc +1 more source
Molecular Oncology, EarlyView.To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley +1 more source
Tradeoffs among indoor air quality, financial costs, and CO2 emissions for HVAC operation strategies to mitigate indoor virus in U.S. office buildings. [PDF]
Build Environ, 2022 Faulkner CA +5 more
europepmc +1 more source
Office building boom and bust [PDF]
Office buildings ; Real property ; Property ...
Randall J. Pozdena
core
Plenty of Bark, But Not Much Bite: Putting Teeth Back into Historic Preservation Enforcement in D.C. [PDF]
, 2007 Washington, D.C. has one of the largest inventories of protected historic buildings of any city in the United States. Over 25,000 structures stand within the city\u27s borders that are either individually landmarked or contributing buildings within a ...
Sale, Winston
core +1 more source
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
Research on energy-saving factors adaptability of exterior envelopes of university teaching-office buildings under different climates (China) based on orthogonal design and EnergyPlus. [PDF]
Heliyon, 2022 Liu Z +5 more
europepmc +1 more source
Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma
Molecular Oncology, EarlyView.Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra +6 more
wiley +1 more source
Chemical contaminant exposures assessed using silicone wristbands among occupants in office buildings in the USA, UK, China, and India. [PDF]
Environ Int, 2021 Young AS +11 more
europepmc +1 more source