Results 71 to 80 of about 3,426,445 (329)
Effect of chemotherapy on passenger mutations in metastatic colorectal cancer
Molecular Oncology, EarlyView.Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui +6 more
wiley +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
La Real Orden en el Despacho del rey: Secretarios, Presidentes y Validos [PDF]
Historia. Instituciones. Documentos, 2012 The Real Orden was created to communicate in an indirect way the commands that the king issued in his dispatch to the Councils, Boards, Courts and other authorities of the Monarchy.
Francisco José Pérez Ramos
doaj
Literature Review of the Definition, Size and Turnover of the Creative Industries and Micro-Businesses in Scotland: Preliminary Research [PDF]
, 2013 This research seeks to review, evaluate and clarify the findings of five recent reports in relation to the discussion paper Creative Industries in Scotland.
Sorensen, Inge
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Molecular Oncology, EarlyView.Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié +13 more
wiley +1 more source
IDENTIFICATION OF EQUIPMENT ON TRACES OF SUBMITTING PAPER MECHANISMS
Теория и практика судебной экспертизы, 2015 The article describes the methodological aspects of conducting identification of research submitting paper mechanisms.
P. A. Chetverkin, A. V. Efimenko
doaj
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Action Office, or, Another Kind of ‘Architecture Without Architects’
Footprint, 2019 When Robert Propst set out to transform the white-collar office, he began with a research protocol: observe, notate, quantify, represent. This process, based equally on the production of data and the use of representation to turn that data into ...
Phillip Denny
doaj +1 more source
Internal Migration of Ethnic Groups in England and Wales by Age and District Type [PDF]
, 2008 This paper examines how internal migration propensities vary by age and ethnic group using data from level 1 (district) scale in England and Wales extracted from the 2001 Census Special Migration Statistics and from tables specially commissioned from the
Hussain, S., Stillwell, J.
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Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source