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Minute by Minute: The Problem of Officials in Official History
Diplomacy & StatecraftThis article explores a persistent dilemma in official history: whether officials should be protected from the loss of anonymity when their confidential advice is published. Since FOI (2000) the problem has recurrd,from its interwar precedent with the publication of British Documents on the Origins of the War (1926–38). Its most controversial voice was
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Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome
FEBS Letters, EarlyView.This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley +1 more source
RichardGomer/modal-split-ui: November 2019 - QrowdLab Official Release
, 2019 Version used in QROWDLab Official, plus the error correction lab ...
Richard Gomer
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FEBS Letters, EarlyView.An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley +1 more source
THE OFFICIAL AND THE NON-OFFICIAL HEALTH AGENCY [PDF]
American Journal of Public Health, 1920 openaire +2 more sources
FEBS Letters, EarlyView.The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson +6 more
wiley +1 more source
Non-Official Higher Education in the UK
, 1999 The full book ‘Non-Official Higher Education in the UK can be found at http://www.gbip.gr/book/24268/Non ...
core