Results 61 to 70 of about 43,003 (262)

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

An Adaptive Offset Tracking Method with SAR Images for Landslide Displacement Monitoring

Remote Sensing, 2017
With the development of high-resolution Synthetic Aperture Radar (SAR) systems, researchers are increasingly paying attention to the application of SAR offset tracking methods in ground deformation estimation. The traditional normalized cross correlation
Jiehua Cai, Changcheng Wang, Xiaokang Mao, Qijie Wang   +3 more
doaj   +1 more source

Exon 7 splicing of ERα predicts poor prognosis and increases phenotypic heterogeneity in luminal a subtype breast cancer

FEBS Open Bio, EarlyView.
ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui, Taobo Hu, Thomson Christian Husein, Wai Hei Shek, Bingrong Chen, Depeng Wang, Shu Wang, Weichuan Yu, Xiaodan Fan, Mengping Long, Toyotaka Ishibashi   +10 more
wiley   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Decision Fusion of D-InSAR and Pixel Offset Tracking for Coal Mining Deformation Monitoring

Remote Sensing, 2018
Ground surface subsidence is a universal phenomenon in coal mining areas which can cause serious damage to the surrounding environment. In this paper, we consider the use of differential interferometric synthetic aperture radar (D-InSAR), multi-temporal ...
Depin Ou, Kun Tan, Qian Du, Yu Chen, Jianwei Ding   +4 more
doaj   +1 more source

Tracking Motor Progression and Device‐Aided Therapy Eligibility in Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To characterise the progression of motor symptoms and identify eligibility for device‐aided therapies in Parkinson's disease, using both the 5‐2‐1 criteria and a refined clinical definition, while examining differences across genetic subgroups.
David Ledingham, Sahana Sathyanarayana, Charlotte B. Stewart, Robyn Iredale, Victoria Foster, Debra Galley, Mark Baker, Nicola Pavese   +7 more
wiley   +1 more source

Seasonal and Interannual Variability of Columbia Glacier, Alaska (2011–2016): Ice Velocity, Mass Flux, Surface Elevation and Front Position

Remote Sensing, 2017
Alaskan glaciers are among the largest contributors to sea-level rise outside the polar ice sheets. The contributions include dynamic discharge from marine-terminating glaciers which depends on the seasonally variable ice velocity.
Saurabh Vijay, Matthias Braun
doaj   +1 more source

Visual Recovery Reflects Cortical MeCP2 Sensitivity in Rett Syndrome

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Rett syndrome (RTT) is a devastating neurodevelopmental disorder with developmental regression affecting motor, sensory, and cognitive functions. Sensory disruptions contribute to the complex behavioral and cognitive difficulties and represent an important target for therapeutic interventions.
Alex Joseph Simon, Nathalie Picard, Valeria d'Andrea, Enchi Chang, Joseph Leffler, Eleonora Centofante, Matthew Taylor, Francesca Bardi, Francesca Cavicchiolo, Takao K. Hensch, Stefano Panzeri, Chinfei Chen, Michela Fagiolini   +12 more
wiley   +1 more source

Fluid and Neuroimaging Biomarkers in Microgliopathy Colony‐Stimulating Factor‐1 Receptor‐Related Disorders

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective This study aims to identify both fluid and neuroimaging biomarkers for CSF1R‐RD that can inform the optimal timing of treatment administration to maximize therapeutic benefit, while also providing sensitive quantitative measurements to monitor disease progression.
Tomasz Chmiela, Madison Reeves, Karen Jansen‐West, Judith Dunmore, Yuping Song, Audrey Strongosky, Sunil Gandhi, Gilana Pikover, Matt Blurton‐Jones, Robert C. Spitale, Erik H. Middlebrooks, Leonard Petrucelli, Mercedes Prudencio, Zbigniew K. Wszolek   +13 more
wiley   +1 more source

Deformation of the Baige Landslide, Tibet, China, Revealed Through the Integration of Cross‐Platform ALOS/PALSAR‐1 and ALOS/PALSAR‐2 SAR Observations

Geophysical Research Letters, 2020
Twenty‐eight ALOS/PALSAR‐1 and ALOS/PALSAR‐2 images acquired from January 2007 to August 2018 were exploited to characterize the deformation history and temporal evolution of the Baige landslide, China, which successively occurred on 11 October and 3 ...
Xiaojie Liu, Chaoying Zhao, Qin Zhang, Zhong Lu, Zhenhong Li   +4 more
doaj   +1 more source