Results 101 to 110 of about 16,974 (127)
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Journal of Antimicrobial Chemotherapy, 1988
Six patients with end-stage chronic renal failure undergoing haemodialysis were given ofloxacin (600 mg) orally and blood samples were taken at intervals up to 32 h. In four patients samples were also taken before and after haemodialysis. Serum concentrations of ofloxacin, desmethyl ofloxacin and ofloxacin N-oxide were measured by HPLC.
L. O. White +3 more
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Six patients with end-stage chronic renal failure undergoing haemodialysis were given ofloxacin (600 mg) orally and blood samples were taken at intervals up to 32 h. In four patients samples were also taken before and after haemodialysis. Serum concentrations of ofloxacin, desmethyl ofloxacin and ofloxacin N-oxide were measured by HPLC.
L. O. White +3 more
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Primary Photophysical Properties of Ofloxacin¶
Photochemistry and Photobiology, 2000Steady-state fluorescence has been used to study the excited singlet state of ofloxacin (OFLX) in aqueous solutions. Fluorescence emission was found to be pH dependent, with a maximum quantum yield of 0.17 at pH 7. Two pKa*s of around 2 and 8.5 were obtained for the excited singlet state.
Jennifer Claridge, Suppiah Navaratnam
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Multiple dose kinetics of ofloxacin and ofloxacin metabolites in haemodialysis patients
European Journal of Clinical Pharmacology, 19927 patients with end-stage renal disease on regular haemodialysis were treated orally with a loading dose of 200 mg ofloxacin and multiple maintenance doses of 100 mg per 24 h for 10 days. The pharmacokinetics of ofloxacin and its metabolites were studied at the end of the treatment period.
Klaus Borner, D. Kampf, A. Pustelnik
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The postantibiotic suppressive effect of l-ofloxacin, an optically active isomer of ofloxacin
Diagnostic Microbiology and Infectious Disease, 1992The postantibiotic suppressive effect (PAE) of L-ofloxacin was studied and compared with those of ciprofloxacin and norfloxacin. The PAE of L-ofloxacin was observed against all Gram-positive organisms tested: Staphylococcus aureus, S. epidermidis, and Enterococcus faecalis.
Kwung P. Fu +2 more
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Penetration of Ofloxacin into Bronchial Secretions
Drugs, 1987The penetration of ofloxacin into bronchial secretions was evaluated in 16 patients after administration of a single oral dose of ofloxacin 400mg. Bronchial secretions were aspirated at bronchoscopy after 1 to 6 hours and serum was collected simultaneously. Ofloxacin concentrations were measured by a microbiological assay method.
J, Symonds +3 more
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2009
Publisher Summary This chapter describes ofloxacin, its general information, physical characteristics, analytical profiles, drug metabolism, and pharmacokinetics. Ofloxacin is a pale yellow or bright yellow crystalline powder, colorless needles from ethanol. The concentrate solution of the drug has a pH of 3.8–5.5 in aqueous. It is slightly soluble in
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Publisher Summary This chapter describes ofloxacin, its general information, physical characteristics, analytical profiles, drug metabolism, and pharmacokinetics. Ofloxacin is a pale yellow or bright yellow crystalline powder, colorless needles from ethanol. The concentrate solution of the drug has a pH of 3.8–5.5 in aqueous. It is slightly soluble in
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Prostatic tissue levels of ofloxacin
Urology, 1991The prostatic tissue levels of ofloxacin were determined in 20 patients undergoing transurethral resection of the prostate. Ofloxacin was administered in two separate dosages of 300 mg PO from twenty-two to two hours preoperatively. The ofloxacin plasma concentrations ranged from 3.73 to 1.85 micrograms/mL at the time of surgery, and the tissue ...
J. Knes, J. Aagaard, Paul O. Madsen
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Drugs, 1987
UTIs are amongst the most frequently encountered problems in primary care practice (Stanton 1973). They are also the most common nosocomial infections, accounting for as many as 40% (Buck & Price 1977). Knowledge of both the prevailing urinary pathogens in the community and hospitals and their susceptibility patterns to available antimicrobial agents ...
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UTIs are amongst the most frequently encountered problems in primary care practice (Stanton 1973). They are also the most common nosocomial infections, accounting for as many as 40% (Buck & Price 1977). Knowledge of both the prevailing urinary pathogens in the community and hospitals and their susceptibility patterns to available antimicrobial agents ...
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Seizures Associated with Ofloxacin Therapy
Clinical Infectious Diseases, 1995We describe four patients who had seizures while receiving ofloxacin; no other causes were evident. Common factors among all patients included advanced age and use of a high-dose regimen. The renal insufficiency of three patients and the timing of the seizures implicate accumulation of ofloxacin as a contributing factor.
Nicholas A. Nackes +4 more
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Intravenous ofloxacin in severe infections
Journal of Antimicrobial Chemotherapy, 1990The efficacy and tolerance of intravenous ofloxacin was studied in 70 patients suffering from soft tissue infections (n = 33), intra-abdominal abscesses (n = 14), septicaemia (n = 12), pneumonia (n = 9) and brucellosis (n = 2). The average daily dose was 6 mg/kg divided into two doses.
R Lackner +5 more
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