Mechanistic modeling of drug products applied to the skin: A workshop summary report
CPT: Pharmacometrics & Systems Pharmacology, 2023 The development of a generic drug product involves demonstrating that there is no significant difference in the rate and extent to which the active ingredient becomes available at the site of action, relative to the reference listed drug product.
Eleftheria Tsakalozou +9 more
doaj +1 more source
Heat Shock Protein 70 Protects the Heart from Ischemia/Reperfusion Injury through Inhibition of p38 MAPK Signaling. [PDF]
, 2020 BackgroundHeat shock protein 70 (Hsp70) has been shown to exert cardioprotection. Intracellular calcium ([Ca2+]i) overload induced by p38 mitogen-activated protein kinase (p38 MAPK) activation contributes to cardiac ischemia/reperfusion (I/R) injury ...
Chen, Qing-Cai +10 more
core +1 more source
SAGE Open, 2023 Information disclosure, participatory governance, and collaborative innovation are open government data’s (OGD) main goals. Understanding the preconditions that enable the efficient and effective implementation of OGD initiatives is essential for ...
Jinhua Chu, You-Yu Dai, Anyuan Zhong
doaj +1 more source
Factors Influencing Citizens’ Intention to Use Open Government Data—A Case Study of Pakistan
Big Data and Cognitive Computing, 2022 Open government data (OGD) has gained much attention worldwide; however, there is still an increasing demand for exploring research from the perspective of its adoption and diffusion.
Muhammad Mahboob Khurshid +5 more
doaj +1 more source
陆军军医大学学报, 2022 Objective To investigate the effects of oxygen and glucose deprivation/recovery (OGD/R) on apoptosis and pyroptosis of A549 cells, and to explore the possibility of the mutual regulation in apoptosis and pyroptosis.
AN Yuxuan +5 more
doaj +1 more source
Modular detergents tailor the purification and structural analysis of membrane proteins including G-protein coupled receptors [PDF]
, 2020 Detergents enable the purification of membrane proteins and are indispensable reagents instructural biology. Even though a large variety of detergents have been developed in the lastcentury, the challenge remains to identify guidelines that allowfine ...
Almeida, F. +12 more
core +2 more sources
Resveratrol promotes the polarization of rat microglial cell line to M2 type with oxygen glucose deprivation/reoxygenation via up-regulating the expression of annexin A1 [PDF]
Jichu yixue yu linchuang, 2021 Objective To explore the role of annexin A1 (ANXA1) in resveratrol regulation of M2 type polarization of rat microglial cell line with oxygen glucose deprivation/reoxygenation (OGD/R) model.
LIN Min, ZHANG Hong-mei
doaj
Biomolecules, 2021 Kaempferol has been shown to protect cells against cerebral ischemia/reperfusion injury through inhibition of apoptosis. In the present study, we sought to investigate whether ferroptosis is involved in the oxygen-glucose deprivation/reperfusion (OGD/R ...
Yuan Yuan +4 more
doaj +1 more source
口腔疾病防治, 2022 Objective Oxygen-glucose deprivation (OGD) is used to mimic ischemia in vitro to observe whether endoplasmic reticulum (ER) stress is involved in human dental pulp cells (hDPCs) after OGD and to better understand the regulatory mechanism of hDPCs in ...
LI Lifen, ZHU Yaqin, JIANG Long
doaj +1 more source
Combined Cyclosporin A and Hypothermia Treatment Inhibits Activation of BV-2 Microglia but Induces an Inflammatory Response in an Ischemia/Reperfusion Hippocampal Slice Culture Model [PDF]
, 2019 Introduction: Hypothermia attenuates cerebral ischemia-induced neuronal cell death associated with neuroinflammation. The calcineurin inhibitor cyclosporin A (CsA) has been shown to be neuroprotective by minimizing activation of inflammatory pathways.
Berger, Felix +5 more
core +1 more source