Results 61 to 70 of about 1,444 (142)

A computable biomedical knowledge object for calculating in‐hospital mortality for patients admitted with acute myocardial infarction

open access: yesLearning Health Systems, 2023
Introduction Quality indicators play an essential role in a learning health system. They help healthcare providers to monitor the quality and safety of care delivered and to identify areas for improvement.
Rosemarie Sadsad   +4 more
doaj   +1 more source

Large-scale evidence generation and evaluation across a network of databases for type 2 diabetes mellitus (LEGEND-T2DM): a protocol for a series of multinational, real-world comparative cardiovascular effectiveness and safety studies

open access: yesBMJ Open, 2022
Introduction Therapeutic options for type 2 diabetes mellitus (T2DM) have expanded over the last decade with the emergence of cardioprotective novel agents, but without such data for older drugs, leaving a critical gap in our understanding of the ...
Rohan Khera   +8 more
doaj   +1 more source

Predictors of diagnostic transition from major depressive disorder to bipolar disorder: a retrospective observational network study

open access: yesTranslational Psychiatry, 2021
Many patients with bipolar disorder (BD) are initially misdiagnosed with major depressive disorder (MDD) and are treated with antidepressants, whose potential iatrogenic effects are widely discussed.
Anastasiya Nestsiarovich   +17 more
doaj   +1 more source

Conceptual design of a generic data harmonization process for OMOP common data model

open access: yesBMC Medical Informatics and Decision Making
Background To gain insight into the real-life care of patients in the healthcare system, data from hospital information systems and insurance systems are required. Consequently, linking clinical data with claims data is necessary.
Elisa Henke   +5 more
doaj   +1 more source

Impact of Regulatory Post‐Market Safety Advisories on Prescribing Practices: An Interrupted Time Series Analysis

open access: yesClinical Pharmacology &Therapeutics, Volume 117, Issue 6, Page 1754-1762, June 2025.
Less frequent adverse drug reactions are usually discovered after a drug's release to the market, making effective and timely communication of regulatory post‐market advisories essential for preventing emerging adverse effects. Time series analysis is a key study design for assessing the impact of post‐market safety advisories.
Seonji Kim   +6 more
wiley   +1 more source

OHDSI Standardized Vocabularies—a large-scale centralized reference ontology for international data harmonization

open access: yesJournal of the American Medical Informatics Association
Abstract Importance The Observational Health Data Sciences and Informatics (OHDSI) is the largest distributed data network in the world encompassing more than 331 data sources with 2.1 billion patient records across 34 countries.
Christian Reich   +7 more
openaire   +3 more sources

Mapping OHDSI OMOP Common Data Model and GA4GH Phenopackets for COVID-19 disease epidemics and analytics

open access: yes, 2022
The COVID-19 crisis demonstrates a critical requirement for rapid and efficient sharing of data to facilitate the global response to this and future pandemics. Our project aims are to enhance interoperability between health and research data by mapping Phenopackets and OMOP schemas, and representing COVID-19 metadata using the FAIR principles to enable
Núria Queralt-Rosinach   +13 more
openaire   +1 more source

Mapping National Vocabularies to International Standards Using OHDSI Standardized Vocabularies

open access: yes
Ensuring semantic interoperability in international studies is crucial. In this context, the mapping of national to international vocabularies is necessary. The Standardized Vocabularies of OHDSI provide such a mapping, which forms the basis for semantic interoperability in the standardized data model OMOP CDM.
Henke, Elisa   +4 more
openaire   +2 more sources

Assessing the harmonization of structured electronic health record data to reference terminologies and data completeness through data provenance

open access: yesLearning Health Systems, Volume 9, Issue 2, April 2025.
Abstract Introduction (1) Assess the harmonization of structured electronic health record data (laboratory results and medications) to reference terminologies and characterize the severity of issues. (2) Identify issues of data completeness by comparing complementary data domains, stratifying by time, care setting, and provenance.
Keith Marsolo   +14 more
wiley   +1 more source

ATC-to-RxNorm mappings – A comparison between OHDSI Standardized Vocabularies and UMLS Metathesaurus

open access: yesInternational Journal of Medical Informatics
The World Health Organization global standard for representing drug data is the Anatomical Therapeutic Chemical (ATC) classification. However, it does not represent ingredients and other drug properties required by clinical decision support systems. A mapping to a terminology system that contains this information, like RxNorm, may help fill this gap ...
Rowdy de Groot   +8 more
openaire   +3 more sources

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