Results 21 to 30 of about 953,364 (296)

Long-term all-sites cancer mortality time trends in Ohio, USA, 1970–2001: differences by race, gender and age

open access: yesBMC Cancer, 2005
Background There were significant changes in cancer mortality in the USA over the last several decades, in the whole country and in particular states. However, no in depth analysis has been published so far, dealing with changes in mortality time trends ...
Tyczynski Jerzy E, Berkel Hans J
doaj   +1 more source

Construction of the Ohio Children's Opportunity Index

open access: yesFrontiers in Public Health, 2022
ObjectiveTo describe the development of an area-level measure of children's opportunity, the Ohio Children's Opportunity Index (OCOI).Data Sources/Study SettingSecondary data were collected from US census based-American Community Survey (ACS), US ...
Naleef Fareed   +7 more
doaj   +1 more source

The ants of Ohio (Hymenoptera, Formicidae): an updated checklist [PDF]

open access: yesJournal of Hymenoptera Research, 2019
I update the last published list of Ohio ants to include 26 new species records and 38 name changes in species already on the list based on literature records, institutional collections, and contemporary collections made by the author or colleagues.
Kaloyan Ivanov
doaj   +3 more sources

The Role of Hematopoietic Cell Transplantation in Ataxia‐Telangiectasia

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Background Ataxia‐telangiectasia (A‐T) is a DNA repair disorder characterized by neurodegeneration, immunodeficiency, and cancer predisposition. Hematopoietic cell transplantation (HCT) is an established therapy in related disorders such as Fanconi anemia (FA) and Nijmegen breakage syndrome (NBS), but its role in A‐T is unclear.
Laila Alkhouli   +3 more
wiley   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

open access: yesFEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

open access: yesFEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Emergence of <i>Ixodes scapularis</i> and <i>Borrelia burgdorferi</i>, the Lyme Disease Vector and Agent, in Ohio

open access: yesFrontiers in Cellular and Infection Microbiology, 2014
Lyme disease, the most common vector-borne disease in the United States, is caused by a tick-borne infection with Borrelia burgdorferi. Currently, Ohio is considered by the Centers for Disease Control and Prevention (CDC) to be non-endemic for Lyme ...
Peng eWang   +6 more
doaj   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

open access: yesMolecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi   +11 more
wiley   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

open access: yesFEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz   +6 more
wiley   +1 more source

Online Mapping Tools for Geolocating Amish Settlements

open access: yesThe Journal of Amish and Plain Anabaptist Studies, 2015
This technical note demonstrates the value of using online mapping tools as a method of geolocating Amish settlements. Primarily using freely available Bing and Google maps and published lists of the addresses of Amish ministers, we geolocated 1,362 ...
Andrew Wilson   +2 more
doaj  

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