Results 41 to 50 of about 1,691,024 (288)
FEBS Letters, EarlyView.Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson +7 more
wiley +1 more source
Top‐oil temperature modelling by calibrating oil time constant for an oil natural air natural distribution transformer [PDF]
IET Generation, Transmission & Distribution, 2020 Integration of low carbon technologies poses a technical challenge on distribution transformers due to the dynamic loading and potentially frequent overloading scenarios. Transformer dynamic thermal rating is hence required, which is the most economical approach to tackle this challenge and ensure a safe operation.
Wang, L +5 more
openaire +3 more sources
Survivin and Aurora Kinase A control cell fate decisions during mitosis
Molecular Oncology, EarlyView.Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir +2 more
wiley +1 more source
Molecular Oncology, EarlyView.CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir +12 more
wiley +1 more source
Overall optimization of natural gas supply chain
You-qi chuyun, 2020 In practical production, many factors should be considered for construction of natural gas supply chain system.However, in most of the researches, the transportation mode considered was single, which could neither effectively solvethe problem of seasonal
Ning XU +5 more
doaj +1 more source
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
Effect of oil mass flow rate on temperature profile in oil wells [PDF]
, 2020 In several design calculations including the development of programs to optimize production, engineers and scientists require accurate prediction of temperature drop due to flow in oil wells.
Afolabi, Lukmon Owolabi +2 more
core +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
A trend deduction model of fluctuating oil prices [PDF]
Crude oil prices have been fluctuating over time and by a large range. It is the disorganization of oil price series that makes it difficult to deduce the changing trends of oil prices in the middle- and long-terms and predict their price levels in the ...
Xu, Haiyan, Zhang, ZhongXiang
core +4 more sources
Journal of Applied Mathematics, 2013 When the conservative governing equation of incompressible fluid flow and heat transfer is discretized by the finite volume method, there are various schemes to deal with the convective term.
Peng Wang +5 more
doaj +1 more source