Results 91 to 100 of about 32,864 (268)

Cancer‐Associated BCL‐2 Mutants Reveal Mechanisms Towards Venetoclax Resistance

Advanced Science, EarlyView.
Venetoclax (VEN) resistance in chronic lymphocytic leukemia arises from diverse BCL2 mutations. We map mechanisms contributing to VEN resistance across common BCL‐2 variants. G101V and D103Y reduce drug binding and increase sequestration of pro‐apoptotic proteins. V156D blocks VEN allosterically.
Jonas Aufdermauer, Ian de Ridder, Mahjoobeh Ehsani, Marasim Khan, Justin Kale, Lukas P. Frenzel, David Andrews, Spyridoula Karamanou, Ana J. Garcia‐Saez, Geert Bultynck   +9 more
wiley   +1 more source

Systematic Evaluation of Ultrasonic In-Line Inspection Techniques for Oil and Gas Pipeline Defects Based on Bibliometric Analysis

Sensors
The global reliance on oil and gas pipelines for energy transportation is increasing. As the pioneering review in the field of ultrasonic defect detection for oil and gas pipelines based on bibliometric methods, this study employs visual analysis to ...
Jie Huang, Pengchao Chen, Rui Li, Kuan Fu, Yanan Wang, Jinyao Duan, Zhenlin Li   +6 more
doaj   +1 more source

SPSB1 Promotes Subcutaneous Adipose Hyperplasia in Facial Port‐Wine Stains by Controlling HDAC1 Degradation and Stability Through Two Distinct Proteolytic Pathways

Advanced Science, EarlyView.
In PWS‐ASPCs, FOSL1 drives the expression of SPSB1. SPSB1, as part of the ESC complex, further binds to HDAC1 and promotes K29‐linked and K48‐linked polyubiquitination of HDAC1. These modifications facilitate the degradation of HDAC1 through the ALP and UPS pathways, respectively.
Hongrui Chen, Bin Sun, Yajing Qiu, Chen Hua, Xiaoxi Lin, Wei Gao   +5 more
wiley   +1 more source

Study on infrasonic leakage monitoring and signal processing for product oil pipeline

You-qi chuyun
Objective With the total length of oil and gas transmission pipelines increasing due to booming development, pipeline leakage monitoring has emerged as one of the critical technologies to ensure the safe and stable operation of these pipelines ...
Yuanbo YIN, Yuxing LI, Wen YANG, Shu LU, Chen ZHANG, Cuiwei LIU, Kai YANG, Wuchang WANG   +7 more
doaj   +1 more source

Integrated Single‐Cell and TCR Profiling Reveals Protection‐Associated CD8+ T Cell Subsets Linked to Viral Control in PRRSV

Advanced Science, EarlyView.
PRRSV vaccine‐mediated protection is associated with clonally expanded cytotoxic CD8+ T cell subsets driven by viral structural proteins and supported by innate TLR4/TLR8 signaling and CD4+ T cell help, whereas non‐protective responses are characterized by dysfunctional exhausted‐like CD8+ T cells linked to poor viral control.
Can Kong, Siang Chen, Maolin Li, Meng Wang, Hailin Zhang, Bolun Zhou, Zhenhua Xie, Chen Wang, Peng Gao, Jianjun Luo, Hanchun Yang, Runsheng Chen, Dongdong Zhang, Jie Li, Jun Han   +14 more
wiley   +1 more source

Adaptive Responses of Tropical Crops: A Multi‐Scale Omics Integrated Perspective

Advanced Science, EarlyView.
Tropical crops integrate genomic, morphological, physiological, and ecological adaptations to thrive under extreme and variable environments. This review highlights how natural selection, domestication, and breeding shape stress resilience, resource‐use strategies, and productivity in sugarcane, banana, cassava, rubber and oil palm, offering new routes
Peilin Wang, Chenhui Li, Dongjiao Wang, Qibin Wu, Zhen Zeng, Huiming Guo, Han Cheng, Songbi Chen, Hongxing Cao, Hongmei Cheng, Jianghui Xie, Youxiong Que   +11 more
wiley   +1 more source

Centrifuge tests on the deformation law of pipelines crossing slopes with different water contents

Scientific Reports
The deformation law of pipelines crossing landslide areas is an important prerequisite for the scientific design of pipelines. Most current studies find it difficult to simulate the real stress and strain state of pipelines on site.
Haidong Jia, Ming Yang, Lianshuang Dai, Yongbing Que, Dongyuan Wang, Zhifeng Yu, Yu Zhao, Wenjun Hu, Junkai Xu, Junfeng Tang   +9 more
doaj   +1 more source

A DPHD model for compressor fault diagnosis based on the fusion of multi-scale deep features and physical priors

You-qi chuyun
ObjectiveExisting intelligent diagnosis methods predominantly rely on purely data-driven models, which are inherently “black-box” and often lack generalization due to the absence of physical information when handling the variable-length, non-stationary ...
Wen YANG, Miao LI, Pengtao NIU, Haoyang SUN, Xinxing JIANG, Qi LIAO, Lingbo LI, Yongtu LIANG   +7 more
doaj   +1 more source

Surface and Interfacial Engineering toward Durable Mechanically Coupled Flexible Electronics

Advanced Science, EarlyView.
This Review highlights how surface and interfacial engineering governs the reliability, durability, and functional stability of mechanically coupled flexible electronics. By integrating fundamental interfacial theory, failure mechanisms, multiscale engineering strategies, and representative applications, it provides a design‐oriented framework for ...
Qian Wang, Fangfang Dai, Wei Wu
wiley   +1 more source

Research on optimization technology of new pipeline design for regional natural gas pipeline network

You-qi chuyun
ObjectiveThe pipeline network has been continuously expanding to accommodate the increasing number of natural gas users and the rising gas consumption. However, the complex structure of the pipeline network, along with the diverse characteristics of gas ...
Jingyi CUI, Kunfeng ZHU, Cuixian GAO, Li GU, Jing REN, Yuxing LI, Wuchang WANG   +6 more
doaj   +1 more source