Results 91 to 100 of about 212,363 (310)

Neuid: A Novel Neuron‐Enriched LncRNA that Connects Epigenetic Gene Silencing to Alzheimer's Disease

Advanced Science, EarlyView.
ABSTRACT The increasing evidence that non‐coding RNAs can become deregulated during pathogenesis is dramatically expanding the space for drug discovery beyond the protein‐coding genome. Long noncoding RNAs (lncRNAs) are emerging as key regulators of cellular function, yet most remain uncharacterized.
Ranjit Pradhan, Zorica Petrovic, M. Sadman Sakib, Sophie Schröder, Dennis Manfred Krüger, Tonatiuh Pena, Eren Diniz, Susanne Burkhardt, Anna‐Lena Schütz, Verena Gisa, Iga Grzadzielewska, Karl Toischer, Thor D. Stein, Jan Krzysztof Blusztajn, Ivana Delalle, Jelena Radulovic, Farahnaz Sananbenesi, Andre Fischer   +17 more
wiley   +1 more source

An end-to-end fault interpretation method driven by visual foundation model with domain adaptation fine-tuning

Scientific Reports
Accurate geological fault interpretation is critical for the safe construction and efficient operation of underground gas storage sites. However, traditional manual interpretation suffers from inefficiency and reliance on expert experience. Existing deep
Yun Liu, Fengyuan Zhang, Huanyu Zou, Famu Huang, Ziheng Zhu, Shijie Zhao, Jinshuo Yan, Sirui Jiang, Jizhou Tang   +8 more
doaj   +1 more source

Research Progress on Interference and Protection of Grounding Electrodes of HVDC Transmission on Buried Pipeline [PDF]

Cailiao Baohu
With the increasing number of high voltage direct current(HVDC) transmission projects in China，the issue of interference from HVDC system grounding electrodes on buried metal pipelines has become increasingly prominent.In order to conduct accurate ...
GAO Jie, TIAN Haizhou, LI Shaofei, LIU Tianhui, GUO Xiaodong, AN Bing, LU Tao
doaj   +1 more source

Caspian oil in global context [PDF]

, 2006
This paper provides a brief overview of the political economy of Caspian oil. It begins by situating the Caspian region’s oil sectors in the larger global market, before proceeding to examine the ways in which the Azerbaijani, Turkmen and Kazakh oil ...
Tompson, William
core  

Timing Mechanotransduction: Mechanically Dynamic Biomaterials Reveal the Temporal Hierarchy of YAP/TAZ Control Nodes

Advanced Science, EarlyView.
This work develops dynamically softening polyacrylamide hydrogels for time‐resolved imaging during continuous mechanical transitions. The study revealed that mechanotransduction is biphasic; YAP/TAZ inactivation is driven by early loss of the nucleocytoskeletal continuum connecting subnuclear adhesions, F‐actin, and the nuclear envelope, coupled with ...
Alessandro Gandin, Giada Vanni, Veronica Torresan, Margherita Pelosin, Rebecca Busetto, Anna Citron, Ambela Suli, Paolo Contessotto, Carlo Albanese, Francesca Zanconato, Tito Panciera, Stefano Piccolo, Giovanna Brusatin   +12 more
wiley   +1 more source

Numerical Study on the Optimal Thermally Affected Region of a Buried Oil Pipeline. [PDF]

ACS Omega, 2023
Xie H, Li C, Wei N, Zhang C, He J.
europepmc   +1 more source

Embedded CRISPRi Enhances Gene‐Silencing Efficiency in Drosophila

Advanced Science, EarlyView.
Current CRISPR interference (CRISPRi) technology in Drosophila has limited efficiency. This study introduces the emCRISPRi platform, which significantly enhances transcriptional silencing efficacy by embedding inhibitory domains within the dCas9 architecture.
Pengchong Fu, Xuedi Zhang, Ying Zhou, Jie Zheng, Angyang Sun, Kailong Zhuang, Weiwei Bao, Guanjun Gao   +7 more
wiley   +1 more source

Greenhouse gas emissions from U.S. crude oil pipeline accidents: 1968 to 2020. [PDF]

Sci Data, 2023
Lu H, Xu ZD, Xu ZD, Song K, Frank Cheng Y, Dong S, Fang H, Peng H, Fu Y, Xi D, Han Z, Jiang X, Dong YR, Gai P, Shan Z, Shan Y.   +15 more
europepmc   +1 more source

Power Optimization of Multi-fluid Transportation Systems [PDF]

, 1990
6th IFAC/IFIP/IFORS/ IMACS Symposium on Information Control Problems in Manufacturing Technology, 26/09/1989. madrid.This paper presents an algorithm for optimizing the energy operating costs in multi-fluid transportation systems.
Camacho, Eduardo F., Ridao Carlini, Miguel Ángel, Ternero Muñiz, Juan Antonio   +2 more
core  

Targeting the PDK1/c‐Myc/SOX10 Signaling in Oligodendrocytes Alleviates Neuropathic Pain

Advanced Science, EarlyView.
This work reveals that oligodendrocyte homeostasis, mediated by PDK1, is a critical determinant of neuropathic pain (NPP) pathogenesis. Disruption of PDK1 in oligodendrocytes impairs SOX10‐dependent myelination programs through c‐Myc accumulation, leading to disrupted myelination and the pathophysiology of NPP.
Pingping Qiao, Lifang Guo, Guochao Yang, Chaoli Huang, He Wang, Jian‐Jun Yang, Guiquan Chen, Yimin Hu   +7 more
wiley   +1 more source