Results 161 to 170 of about 2,794 (294)

Targeted senotherapy improves electrographic and behavioral outcomes in a mouse model of temporal lobe epilepsy

Epilepsia, EarlyView.
Abstract Objective Current pharmacotherapy for temporal lobe epilepsy (TLE) is limited to symptomatic treatment and leaves approximately one third of patients with inadequate seizure control. Discovering disease‐modifying targets is an unmet clinical need. We have previously identified senescent cells (SCs) as one such target. Many drugs that eliminate
David J. McFall, Abbas I. Hussain, Michelle Cho, Patrick A. Forcelli   +3 more
wiley   +1 more source

The Influence of Moisturizer Co-Application Protocols on In Vitro Penetration of Betamethasone in Porcine Skin. [PDF]

Pharmaceutics
Rost DL, Barbalho GN, Andrade JFM, Cunha-Filho M, Gelfuso GM, Gratieri T.   +5 more
europepmc   +1 more source

Unique deficits in place coding across subfields of the hippocampus in a mouse model of temporal lobe epilepsy

Epilepsia, EarlyView.
Abstract Objective Memory problems are comorbid with temporal lobe epilepsy (TLE). Animal models of TLE reveal impairments in spatial firing fields of hippocampal place cells, providing a potential neural substrate for memory problems. Each subfield of the hippocampus carries out unique aspects of spatial memory, yet little is known about how ...
Brittney L. Boublil, Margaret M. Donahue, Cathy B. Dang, Gergely Tarcsay, Laura A. Ewell   +4 more
wiley   +1 more source

Neomycin sulfate and triamcinolone acetonide suspended ointment designed for transdermal delivery: formulation and in vitro evaluation. [PDF]

Saudi Pharm J
Wu J, Tang Q, Zhao X, Shen Y, Liao R, Zhang H, Feng X, Shi A.   +7 more
europepmc   +1 more source

Cannabidiol reduces atypical absence seizures and epileptic spasms in a Gabrb3+/D120N mouse model of Lennox–Gastaut syndrome

Epilepsia Open, EarlyView.
Abstract Objective Lennox–Gastaut syndrome (LGS) is a drug‐resistant developmental and epileptic encephalopathy (DEE). Preclinical drug development for LGS is constrained by a lack of syndrome‐relevant animal models. We aimed to evaluate a Gabrb3+/D120N knock‐in (KI) mouse model of LGS by quantifying atypical absence seizures and epileptic spasms and ...
Thomas Harman, Laura A. Sharman, Ka Lai Yip, Miguel Bedoya‐Pérez, Vaishali Janve, Jonathon C. Arnold   +5 more
wiley   +1 more source

Comparison of the Effectiveness Differences between Western and Chinese Medicinal Ointments against Eczema. [PDF]

Pharmaceuticals (Basel)
Law SK, Wang Y, Wu XX.
europepmc   +1 more source

Leptin Reduces Running in a Rodent Anorexia Nervosa Model via a Distributed Neural Network

European Eating Disorders Review, EarlyView.
ABSTRACT Objective Hyperactivity is a persistent and clinically relevant symptom in anorexia nervosa (AN). Hyperactivity is inversely correlated with leptin levels. While systemic leptin administration attenuates hyperactivity in rodent models, the specific brain regions mediating this effect remain unclear.
Nick J. M. Papavoine, Melissa N. Veendijk, Jessie Nijman, Mieneke C. M. Luijendijk, Inge G. Wolterink‐Donselaar, Frank J. Meye, Roger A. H. Adan   +6 more
wiley   +1 more source

Role of Polyethylene Glycol in Dermatology. [PDF]

Indian Dermatol Online J
Patel V, Gaurav V.
europepmc   +1 more source

Optimization and Cost Evaluation of an Autonomous Hybrid Renewable Energy System for Electrifying Rural Areas in Nigeria

Energy Science &Engineering, EarlyView.
This research explores the techno‐economic and environmental performance of fully renewable hybrid energy systems for rural electrification in Auchi, Nigeria. HOMER Pro is utilized to model and optimize PV/WT/Battery, PV/Battery, and WT/Battery configurations under identical conditions.
Ibrahim Seidu, Sani Salisu, Abdullahi Abubakar Mas'ud, Umar Musa, Ibrahim Abdullahi Shehu, Adamu Abubakar Sa'idu, Firdaus Muhammad‐Sukki, Mohd Khairul Amri Kamarudin   +7 more
wiley   +1 more source

Nanostructured propolis ointment and platelet-rich plasma as novel biotherapeutics for cutaneous wound repair in an experimental canine model. [PDF]

Discov Nano
Wafy MN, Hassan EA, Saeed S, Khattab MS, AbuBakr HO, Yassin AM, Abu-Seida AM.   +6 more
europepmc   +1 more source