Results 11 to 20 of about 880 (162)

Bioorthogonal CRISPR/Cas9-Drug Conjugate: A Combinatorial Nanomedicine Platform. [PDF]

Adv Sci (Weinh), 2023
Here, a nanomedicine platform based on bioorthogonal CRISPR/Cas9‐drug conjugates, which can be self‐delivered in vivo and exert strong anti‐tumor effects upon gene editing and chemotherapy is developed. The current development provides a powerful strategy that can be widely applied for the therapy of human diseases such as cancer and genetic disorders.
Beha MJ, Kim JC, Im SH, Kim Y, Yang S, Lee J, Nam YR, Lee H, Park HS, Chung HJ.   +9 more
europepmc   +2 more sources

Olaparib synergy screen reveals Exemestane induces replication stress in triple-negative breast cancer. [PDF]

Mol Oncol
Screening 166 FDA‐approved anticancer drugs identifies the aromatase inhibitor Exemestane as a synergistic partner of PARP inhibitor Olaparib in BRCA‐proficient triple‐negative breast cancer. Exemestane induces ROS‐mediated replication stress, enhancing DNA damage and apoptosis alongside Olaparib.
Yusoh NA, Su L, Chia SL, Tian X, Ahmad H, Gill MR.   +5 more
europepmc   +2 more sources

Concomitant inhibition of the thioredoxin system and nonhomologous DNA repair potently sensitizes Philadelphia-positive lymphoid leukemia to tyrosine kinase inhibitors. [PDF]

Hemasphere
Abstract Breakpoint cluster region‐Abelson (BCR::ABL1) gene fusion is an essential oncogene in both chronic myeloid leukemia (CML) and Philadelphia‐positive (Ph+) B‐cell acute lymphoblastic leukemia (B‐ALL). While tyrosine kinase inhibitors (TKIs) are effective in up to 95% of CML patients, 50% of Ph+ B‐ALL cases do not respond to treatment or relapse.
Komorowski L, Dabkowska A, Madzio J, Pastorczak A, Szczygiel K, Janowska M, Fidyt K, Bielecki M, Hunia J, Bajor M, Stoklosa T, Winiarska M, Patkowska E, Firczuk M.   +13 more
europepmc   +2 more sources

Unmatched Cell Line Collections Are Not Optimal for Identification of PARP Inhibitor Response and Drug Synergies. [PDF]

J Cell Mol Med
ABSTRACT PARP inhibitors show great efficacy in BRCA1/2‐mutated patients, but many preclinical studies, including combination therapies, fail to translate clinically, likely due to the limitations of preclinical models. This brief report aimed to identify appropriate cell line models to investigate PARP inhibitor sensitivity and synergies. An in silico
Phan Z, Fernandez KJ, Caldon CE.
europepmc   +2 more sources

Artificial intelligence-assisted ultrasound-guided regional anaesthesia: An explorative scoping review. [PDF]

J Exp Orthop
Abstract Purpose The present study reviews the available scientific literature on artificial intelligence (AI)‐assisted ultrasound‐guided regional anaesthesia (UGRA) and evaluates the reported intraprocedural parameters and postprocedural outcomes.
Marino M, Hagh R, Hamrin Senorski E, Longo UG, Oeding JF, Nellgard B, Szell A, Samuelsson K.   +7 more
europepmc   +2 more sources

Integrated Performance and Visualization Enhancement of OLAP Using Growing Self Organizing Neural Networks

Journal of Advances in Information Technology, 2010
OLAP performance and its data visualization can be improved using different types of enhancement techniques. Previous research has taken two separate directions in OLAP performance improvement and visualization enhancement respectively. Some recent works
Muhammad Usman, Sohail Asghar, Simon Fong   +2 more
doaj   +1 more source

Optimizing the digital customer journey—Improving user experience by exploiting emotions, personas and situations for individualized user interface adaptations

Journal of Consumer Behaviour, Volume 22, Issue 5, Page 1050-1061, September/October 2023., 2023
Abstract This paper discusses a novel approach for exploiting emotions and situation‐aware software adaptation methods for individualizing some of the touch points of the digital customer journey and thereby optimizing customer experience and effectiveness of e‐commerce applications.
Christian Märtin, Bärbel Christine Bissinger, Pietro Asta   +2 more
wiley   +1 more source

Querying data warehouses efficiently using the Bitmap Join Index OLAP Tool

CLEI Electronic Journal, 2012
Data warehouse and OLAP are core aspects of business intelligence environments, since the former store integrated and time-variant data, while the latter enables multidimensional queries, visualization and analysis.
Anderson Chaves Carniel, Thiago Luís Lopes Siqueira   +1 more
doaj   +1 more source

Retracted: Data exploration of college students' humanistic literacy in the internet age under the big data environment

IET Software, Volume 17, Issue 4, Page 649-660, August 2023., 2023
Abstract Retraction: [Taixiang Tang, Huihua Zhang, Data exploration of college students' humanistic literacy in the internet age under the big data environment, IET Software 2023 (https://doi.org/10.1049/sfw2.12087)]. The above article from IET Software, published online on 20 January 2023 in Wiley Online Library (wileyonlinelibrary.com), has been ...
Taixiang Tang, Huihua Zhang
wiley   +1 more source

The Use of Column-Based DBMSS to Form Multidimensional Data Structures

Современные информационные технологии и IT-образование, 2023
The work is devoted to the analysis of the method of designing information systems using the “Data vault” modeling technology. The described approach can be used when building a data warehouse within a multidimensional information system based on the ...
Dmitry Kunitsky, Maxim Fomin
doaj   +1 more source