Results 11 to 20 of about 6,412 (177)

Bioorthogonal CRISPR/Cas9-Drug Conjugate: A Combinatorial Nanomedicine Platform. [PDF]

Adv Sci (Weinh), 2023
Here, a nanomedicine platform based on bioorthogonal CRISPR/Cas9‐drug conjugates, which can be self‐delivered in vivo and exert strong anti‐tumor effects upon gene editing and chemotherapy is developed. The current development provides a powerful strategy that can be widely applied for the therapy of human diseases such as cancer and genetic disorders.
Beha MJ, Kim JC, Im SH, Kim Y, Yang S, Lee J, Nam YR, Lee H, Park HS, Chung HJ.   +9 more
europepmc   +2 more sources

Olaparib synergy screen reveals Exemestane induces replication stress in triple-negative breast cancer. [PDF]

Mol Oncol
Screening 166 FDA‐approved anticancer drugs identifies the aromatase inhibitor Exemestane as a synergistic partner of PARP inhibitor Olaparib in BRCA‐proficient triple‐negative breast cancer. Exemestane induces ROS‐mediated replication stress, enhancing DNA damage and apoptosis alongside Olaparib.
Yusoh NA, Su L, Chia SL, Tian X, Ahmad H, Gill MR.   +5 more
europepmc   +2 more sources

Concomitant inhibition of the thioredoxin system and nonhomologous DNA repair potently sensitizes Philadelphia-positive lymphoid leukemia to tyrosine kinase inhibitors. [PDF]

Hemasphere
Abstract Breakpoint cluster region‐Abelson (BCR::ABL1) gene fusion is an essential oncogene in both chronic myeloid leukemia (CML) and Philadelphia‐positive (Ph+) B‐cell acute lymphoblastic leukemia (B‐ALL). While tyrosine kinase inhibitors (TKIs) are effective in up to 95% of CML patients, 50% of Ph+ B‐ALL cases do not respond to treatment or relapse.
Komorowski L, Dabkowska A, Madzio J, Pastorczak A, Szczygiel K, Janowska M, Fidyt K, Bielecki M, Hunia J, Bajor M, Stoklosa T, Winiarska M, Patkowska E, Firczuk M.   +13 more
europepmc   +2 more sources

Optimizing the digital customer journey—Improving user experience by exploiting emotions, personas and situations for individualized user interface adaptations

Journal of Consumer Behaviour, Volume 22, Issue 5, Page 1050-1061, September/October 2023., 2023
Abstract This paper discusses a novel approach for exploiting emotions and situation‐aware software adaptation methods for individualizing some of the touch points of the digital customer journey and thereby optimizing customer experience and effectiveness of e‐commerce applications.
Christian Märtin, Bärbel Christine Bissinger, Pietro Asta   +2 more
wiley   +1 more source

Artificial intelligence-assisted ultrasound-guided regional anaesthesia: An explorative scoping review. [PDF]

J Exp Orthop
Abstract Purpose The present study reviews the available scientific literature on artificial intelligence (AI)‐assisted ultrasound‐guided regional anaesthesia (UGRA) and evaluates the reported intraprocedural parameters and postprocedural outcomes.
Marino M, Hagh R, Hamrin Senorski E, Longo UG, Oeding JF, Nellgard B, Szell A, Samuelsson K.   +7 more
europepmc   +2 more sources

Unmatched Cell Line Collections Are Not Optimal for Identification of PARP Inhibitor Response and Drug Synergies. [PDF]

J Cell Mol Med
ABSTRACT PARP inhibitors show great efficacy in BRCA1/2‐mutated patients, but many preclinical studies, including combination therapies, fail to translate clinically, likely due to the limitations of preclinical models. This brief report aimed to identify appropriate cell line models to investigate PARP inhibitor sensitivity and synergies. An in silico
Phan Z, Fernandez KJ, Caldon CE.
europepmc   +2 more sources

Towards Intensional Answers to OLAP Queries for Analytical Sessions [PDF]

, 2012
International audienceOne of the problems in analyzing large multidimensional databases through OLAP sessions is that decision makers can be overwhelmed by the size of query answers, while they need a concise summary of data.
Marcel, Patrick, Missaoui, Rokia, Rizzi, Stefano, Stefano Rizzi, Rokia Missaoui, R. Missaoui, Patrick Marcel, P. Marcel   +7 more
core   +1 more source

Benchmarking Exploratory OLAP [PDF]

, 2017
Supporting interactive database exploration (IDE) is a problem that attracts lots of attention these days. Exploratory OLAP (On-Line Analytical Processing) is an important use case where tools support navigation and analysis of the most interesting data, using the best possible perspectives.
Djedaini, Mahfoud, Furtado, Pedro, Labroche, Nicolas, Marcel, Patrick, Peralta, Veronika   +4 more
openaire   +2 more sources

Gestão do Conhecimento Utilizando o Dw/Olap Aplicado nas Organizações [PDF]

, 2006
Neste trabalho são feitas quatro abordagens. Na primeira apresenta-se a disciplina de Gestão do Conhecimento, onde se encontra definições, o papel da TI, sucessos e possíveis falhas na implantação de projetos da Gestão do Conhecimento.
Perfeito, Juarez, Heil, Jeferson, Dalfovo, Oscar, Selig, Paulo Mauricio   +3 more
core  

Towards ontology-based OLAP

, 2012
Understandability, reuse, and maintainability of analytical queries belong to the key challenges of Data Warehousing, especially in settings where a large number of business analysts work together and need to share knowledge.
Anderlik, S., Bernd Neumayr, Stefan Anderlik, Neumayr, B., Michael Schrefl, Schrefl, M.   +5 more
core   +1 more source