Results 111 to 120 of about 6,318,850 (309)

Insights into a long life without cancer: The case of the bowhead whale

Molecular Oncology, EarlyView.
Long‐lived, large‐bodied organisms have evolved powerful anticancer mechanisms that preserve cellular and tissue integrity across extended lifespans. A recent study by Firsanov et al. shows that greater genome stability is a key factor underlying the remarkable longevity and cancer resistance of one such species, the bowhead whale.
Inés Paniagua, Johanna A. Joyce
wiley   +1 more source

Old Age Stigmatization

, 2015
Surprisingly, the discourse on ageism hardly profits from stigma research despite their common denominator—discrimination. The goal of this article is to discuss the stigma concept developed on micro-level interactions and apply it to ageism research on the macro level, i.e. using Round 4 data of the representative international European Social Survey
openaire   +3 more sources

Iron homeostasis disruption and lipid peroxidation in skeletal muscle during short‐term immobilization

FEBS Open Bio, EarlyView.
14‐day casting‐induced immobilization reduced gastrocnemius muscle mass and increased non‐heme iron and ferritin heavy chain levels. Despite iron accumulation, transferrin receptor 1 and iron regulatory protein 2 were paradoxically upregulated. Lipid peroxidation was elevated without compensatory antioxidant responses.
Haruka Yokogawa, Kazuhiko Higashida, Naoya Nakai   +2 more
wiley   +1 more source

Optimization of Starburst99 for Intermediate-Age and Old Stellar Populations

, 2004
We have incorporated the latest release of the Padova models into the evolutionary synthesis code Starburst99. The Padova tracks were extended to include the full asymptotic giant branch (AGB) evolution until the final thermal pulse over the mass range 0.
Bertelli G., Blocker T., Blocker T., Bressan G., Cervino M., Charbonnel C., Charbonnel C., Claus Leitherer, de Jager C., Dorfi E. A., Fagotto F., Fagotto F., Fioc M., Gerardo A. Vazquez, Grevesse N., Groenewegen M. A. T., Hannaford P., Kudritzki R. P., Kudritzki R. P., Langer N., Maeder A., Maeder A., Marigo P., Meynet G., Pauldrach A. W. A., Reimers D., Renzini A., Schaerer D., Schaerer D., Schaerer D., Schaller G., Schonberner D., Ventura P., Wagenhuber J., Weidemann V.   +34 more
core   +2 more sources

The skills required for transition to university and study in biological sciences: A student perspective

FEBS Open Bio, EarlyView.
Bioscience students were asked for their opinions on the value and teaching of skills. 204 responded that teamwork, time management and study skills are necessary to reach University, that scientific writing, research, laboratory and presentation skills are taught effectively during their studies, while other skills are gained inherently through study ...
Janella Borrell, Susan Crennell
wiley   +1 more source

Exposing ageism [PDF]

, 2000
Throughout much of the past century, old age was considered as a social problem. However, a sociological analysis of old age clearly indicates that the weak position of older people in society is ultimately a result of hegemonic ideological manoeuvres ...
Formosa, Marvin
core  

Effectiveness of unilateral lower-limb exoskeleton robot on balance and gait recovery and neuroplasticity in patients with subacute stroke: a randomized controlled trial

Journal of NeuroEngineering and Rehabilitation
Background Impaired balance and gait in stroke survivors are associated with decreased functional independence. This study aimed to evaluate the effectiveness of unilateral lower-limb exoskeleton robot-assisted overground gait training compared with ...
Congcong Huo, Guangjian Shao, Tiandi Chen, Wenhao Li, Jue Wang, Hui Xie, Yan Wang, Zengyong Li, Pengyuan Zheng, Liguo Li, Luya Li   +10 more
doaj   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

The classification of mild cognitive impairment or healthy ageing improves when including practice effects derived from a semantic verbal fluency task

Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring
INTRODUCTION Practice effects are an improvement in task performance with repeated testing. Their absence may indicate compromised learning and may help discriminate healthy from pathological ageing.
Felix Dörr, Loris Grandjean, Johannes Tröger, Jessica Peter   +3 more
doaj   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source