Results 61 to 70 of about 2,539,217 (317)
FEBS Letters, EarlyView.Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara +3 more
wiley +1 more source
Practical Psychiatry of Old Age, Fifth Edition [PDF]
, 2013 Multi-disciplinary in its approach, this book details key psychiatric conditions, their assessment and management in line with modern developments, including the latest developments in healthcare policy.
Wattis, John, Curran, Stephen
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Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Old age mortality in South Africa [PDF]
, 2009 Includes bibliographical references (leaves 71-74).This study estimates the mortality of the South African oldest old age population (in five year age groups from age 75 up to the open age interval 100 and above) and in the process re-estimates the ...
Machemedze, Takwanisa
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Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
Old Age Pension Committee letter to George Cotterill regarding his position on pensions, August 20, 1932 [PDF]
, 1932 The Old Age Pension Committee writes to George Cotterill after he has begun his campaign for Congress in Washington State to inquire about his position on pension plans. They write that they would like to know his stance on the Dill-Conery Bill.
Old Age Pension Committee
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Behavioural Neurology, 1994 Thirty-seven patients with neuropathologically verified Alzheimer's disease (AD) have been studied prospectively. A principal components analysis of neuron numbers in cortical and subcortical areas revealed two variables: Variable I with high loadings ...
H. Förstl +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
The functional neuroanatomy of event-based and time-based prospective memory, and its improvement
Communications BiologyProspective memory anchors upcoming activities in future time and space either cued externally (event-based prospective memory) or internally (time-based prospective memory). It is key to remain autonomous and can be enhanced using incentives. To examine
Jessica Peter +9 more
doaj +1 more source