Results 81 to 90 of about 2,539,217 (317)

Unhappiness, health and cognitive ability in old age [PDF]

, 2008
Background To test whether scores on depression inventories on entry to a longitudinal study predict mental ability over the next 4–16 years. Method Associations between scores on the Beck Depression Inventory and on tests of intelligence, vocabulary and
Ibrahim, S, Cobain, M., Cobain, M, McInnes, Lynn, Rabbitt, P, Lunn, M, Ibrahim, S.; id_orcid, McInnes, L., Lunn, M., Ibrahim, Said, McInnes, L, Rabbitt, Patrick, Rabbitt, P.   +12 more
core   +1 more source

Virtual reality-based training may improve visual memory and some aspects of sustained attention among healthy older adults – preliminary results of a randomized controlled study

BMC Psychiatry
Background/Aims Older age and cognitive inactivity have been associated with cognitive impairment, which in turn is linked to economic and societal burdens due to the high costs of care, especially for care homes and informal care.
Ewa Szczepocka, Łukasz Mokros, Jakub Kaźmierski, Karina Nowakowska, Anna Łucka, Anna Antoszczyk, Javier Oltra-Cucarella, Walter Werzowa, Martin Hellevik, Stavros Skouras, Karsten Bagger   +10 more
doaj   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Deep sleep slow wave–spindle coupling is selectively linked to plasma amyloid-β levels in older adults in clinical trials

Scientific Reports
Slow wave activity, the signature of deep/slow wave sleep, has consistently been linked to amyloid-beta (Aβ), a biomarker of neurodegeneration. Less is known about how Aβ relates to specific microstructural processes within slow wave sleep, such as the ...
Marina Wunderlin, Korian Wicki, Charlotte Elisabeth Teunissen, Marc Alain Züst   +3 more
doaj   +1 more source

Near-Infrared Stimulation in Psychiatry Disorders: A Systematic Review of Efficacy and Biological Mechanisms

NeuroSci
Background: Photobiomodulation (PBM), also referred to as low-level light therapy (LLLT), is an emerging non-pharmacological approach. This treatment is considered low-risk, cost-effective, and non-invasive, utilizing near-infrared light (NIR).
Joanna Woźniak, Michał Pazdrak, Ada Domanasiewicz, Jakub Kaźmierski   +3 more
doaj   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Attitudes of the Retired and Elderly, 1974 [PDF]

, 1979
copyright UK Data Service and data collection copyright owner.To collect information on how older people feel about their retired situation and the way society treats them.Main Topics:Attitudinal/Behavioural Questions Reasons for recent moves ...
Age Concern
core   +1 more source

Moderating effects of gender, age and cognitive reserve on combined cognitive training and transcranial electrical stimulation

Brain Stimulation, 2023
Christine Krebs, Jessica Peter, Esther Brill, Stefan Klöppel, Anna-Katharine Brem   +4 more
doaj   +1 more source

Practice improves older adults’ attentional control and prospective memory more than HD-tDCS: a randomized controlled trial

Scientific Reports
Frontal and parietal brain regions are involved in attentional control and prospective memory. It is debated, however, whether increased or decreased activity in those regions is beneficial for older adults’ task performance.
Nadine Schmidt, Marta Menéndez-Granda, Ronya Münger, Adamantini Hatzipanayioti, Matthias Kliegel, Michael Orth, Jessica Peter   +6 more
doaj   +1 more source

Acute caffeine treatment protects the developing retina from ischemia‐induced cell death

FEBS Open Bio, EarlyView.
Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento, Danniel Pereira‐Figueiredo, Gabriella Grossi de Lima Dias, Gabriel Ferreira dos Santos, Mariana Rodrigues Pereira, Rafael Brito, Karin C Calaza   +6 more
wiley   +1 more source