Results 21 to 30 of about 955,969 (257)

Retrospective life course data from European countries on how early life experiences determine health in old age and possible mid-life mediators

open access: yesData in Brief, 2017
The data presented in this article is related to the research paper entitled “The long arm of childhood circumstances on health in old age: Evidence from SHARELIFE” (E. Pakpahan, R. Hoffmann, H. Kröger, 2016) [1].
Eduwin Pakpahan   +2 more
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

An investigation into the age structure of Norway spruce and Scots pine stands in Norway

open access: yesEcological Indicators
Forest age structure is one of the most important ecological indicators of forest sustainability in terms of biodiversity, forest history, harvesting potentials, carbon storage, and recreational values. The available information on the forest age is most
Aaron Smith   +2 more
doaj   +1 more source

Prevalence and Analytic Study of Diabetic Patients in Al-Bayda, Libya

open access: yesمجلة المختار للعلوم, 2017
The aim of this study was to find out the prevalence and analyzing some parameters including family history and duration of diabetic foot among diabetic patients in El-Beyda city.
Heba. Shareaf   +2 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

"The Industrial Scrap Heap": Technological Unemployment, Obsolescence and Older Workers in the Early Twentieth Century US

open access: yestripleC: Communication, Capitalism & Critique
Early 20th century workers, organisers, and social advocates argued that technological imposition by industry and its associated impact on older workers led to both the need and possibility to socialise old age economic security in the United States ...
Amanda Ciafone
doaj   +1 more source

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

open access: yesFEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara   +3 more
wiley   +1 more source

Design and analysis strategies for robust microbiome ageing research

open access: yesFEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik   +5 more
wiley   +1 more source

Predictive factors of urinary tract infections among the oldest old in the general population. a population-based prospective follow-up study

open access: yesBMC Medicine, 2011
Background Urinary tract infections (UTI) are common among the oldest old and may lead to a few days of illness, delirium or even to death. We studied the incidence and predictive factors of UTI among the oldest old in the general population. Methods The
Cools Herman JM   +3 more
doaj   +1 more source

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