Results 121 to 130 of about 3,988,688 (305)
IGF2 knockout reduces but does not abolish osteosarcoma growth in vitro and in vivo
FEBS Open Bio, EarlyView.To test whether endogenous IGF2 promotes osteosarcoma growth, IGF2 was knocked out in Saos2 cells via CRISPR‐Cas9. KO cells showed reduced proliferation in vitro, and knockout xenografts in mice reached only ~25% of wild‐type tumor volume. Insulin‐like growth factor 2 (IGF2) is implicated in osteosarcoma, but direct functional evidence of its role is ...
Shun Yao, Marco Archetti
wiley +1 more source
Confirmer votre participation à MAPS 13
, 2019 Bienvenue dans l'aventure MAPS 13 ! Cette page sera ouverte à partir du 9 mars 2020. À réception du mail indiquant que vous êtes retenus pour participer à MAPS 13, vous devrez confirmer votre participation à MAPS 13 en ligne (précisions à venir).
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FEBS Open Bio, EarlyView.TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao +10 more
wiley +1 more source
Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level
Aging and Cancer, EarlyView.This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley +1 more source
Aging and Cancer, EarlyView.In patients with malignant ureteral obstruction undergoing percutaneous nephrostomy, sarcopenia defined by a low psoas muscle index was independently associated with poor overall survival on multivariate Cox regression analysis, suggesting that preoperative assessment of psoas muscle index may aid prognostic stratification in this population.
Kota Shimokihara +3 more
wiley +1 more source
Appel à candidature MAPS 10, c'est parti!
, 2017 Ouverture de l'appel à candidature MAPS 10 ! La MAPS Team est ravie de lancer le premier appel à candidature pour l’école thématique MAPS 10 qui se tiendra du 18 au 23 juin 2017 à Oléron!
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, 2016 La guest list de MAPS 9 est disponible ici: Amalric Marion Amblard Frederic Becu Nicolas Caffara Amelia Corson Nathalie Gaudou Benoit Marilleau Nicolas Rey Sebastien Rousseaux Frederic Sheeren David Salze Paul Romain Reulier Romain Reuillon Brice ...
Réseau MAPS
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Aging and Cancer, EarlyView.Cancer treatment is associated with measurable acceleration of biological aging across epigenetic, telomere, senescence, and immune biomarkers. However, biomarker validation and interventional strategies remain limited, especially in hematologic malignancies, underscoring the need for standardized multi‐omic aging assessments and adequately powered ...
Moataz Ellithi +3 more
wiley +1 more source
NTU Journal of Engineering and TechnologyResearch and practical applications to update maps depend on successive steps and take into account the development of surveying devices and methods of producing old cadastral maps. which are the only maps available for ownership in Iraq, and that Iraqi
Hasham Mohameed Abdalhadee +1 more
doaj +1 more source