Results 81 to 90 of about 13,500 (205)

The effect of activities of daily living on anxiety in older adult people: the mediating role of social participation

Frontiers in Public Health
ObjectiveAnxiety is a serious psychiatric illness in older adult people. Activities of daily living and social participation are important factors influencing anxiety in older adult people.
Juan Zheng, Jianqiang Xu, Daqi Liu
doaj   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

10. Older Adults [PDF]

Diabetes Care, 2015
openaire   +2 more sources

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

The impact of social participation on the health status of the older adult: An empirical study based on CGSS 2021 data.

PLoS ONE
IntroductionWith the rapid pace of population aging, the health issues of the older adult have garnered widespread attention. Social participation plays a pivotal role in the health of the older adult.
Zebo Zhang, Lei Jin, Jiajun Liu, Dongling Liao, Xiaolin Zhang   +4 more
doaj   +1 more source

Dietary patterns influencing the human colonic microbiota from infancy to centenarian age: a narrative review

Frontiers in Nutrition
Our dietary choices not only affect our body but also shape the microbial community inhabiting our large intestine. The colonic microbiota strongly influences our physiology, playing a crucial role in both disease prevention and development.
Vitor Geniselli da Silva, Vitor Geniselli da Silva, Nicole Clémence Roy, Nicole Clémence Roy, Nicole Clémence Roy, Nick William Smith, Clare Wall, Clare Wall, Jane Adair Mullaney, Jane Adair Mullaney, Jane Adair Mullaney, Warren Charles McNabb, Warren Charles McNabb   +12 more
doaj   +1 more source

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source

Challenges of learning English in late adulthood: The case of online learning

International Journal of Educational Spectrum
Foreign language learning has been found effective in helping older people improve cognitive functioning and provide opportunities at psychological and social levels.
Ebru Noyan, Asuman Aşık
doaj   +1 more source

11. Older Adults [PDF]

Diabetes Care, 2016
openaire   +2 more sources