Results 161 to 170 of about 9,063,075 (357)
Molecular Oncology, EarlyView.CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak +10 more
wiley +1 more source
Frontiers in Public HealthPopulation ageing is a significant trend in social development and will remain a fundamental national condition in China for the foreseeable future.
Denghui Huang, Ran Feng, Minxuan Shi
doaj +1 more source
Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source
Investigating User Authentication in the Context of Older Adults
Knowledge-based authentication is almost ubiquitous due to low cost and relatively straightforward implementation. Despite its popularity, there are some well-known problems associated with knowledge-based authentication, such as the cognitive load of ...
Nicholson, James
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Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
The role of executive attention in healthy older adults' concurrent walking and counting
, 2014 Completing activities of daily life relies on using both cognitive and physical resources efficiently, but these are affected by age. This may be due either to an age-related reduction in the resources we have available for carrying out tasks or to a ...
Maclean, Linda MacArthur
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A qualitative study of alcohol, health and identities among UK adults in later life
, 2013 Increasing alcohol consumption among older individuals is a public health concern. Lay understandings of health risks and stigma around alcohol problems may explain why public health messages have not reduced rates of heavy drinking in this sector.
Haighton, Catherine A. +21 more
core +1 more source
Journal of Asian Architecture and Building EngineeringThis paper aims to clarify the spatial arrangement of house in Nonmuang Community, Khon Kaen, Thailand. As Thailand moves toward a super-aged society, understanding how everyday domestic spaces support aging in place is increasingly important, especially
Nayatat Laopaiboon Tonmitr +1 more
doaj +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Alcohol and prescription drug safety in older adults
, 2013 Faika Zanjani,1,2 Aasha I Hoogland,1 Brian G Downer11Department of Gerontology, 2Building Interdisciplinary Research Careers in Women's Health University of Kentucky, Lexington, KY, USABackground: The objectives of this study were to investigate ...
Zanjani F, Hoogl, AI, Downer BG
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