Results 151 to 160 of about 9,063,075 (357)

Where Would You Turn for Help? Older Adults’ Awareness of Community Health and Support Services for Dementia Care [PDF]

Previous findings on older adults’ awareness of community support services (CSSs) have been inconsistent and marred by acquiescence or over-claiming bias. To address this issue, this study used a series of 12 vignettes to describe common situations faced
Brian Hutchison, Joseph Tindale, Kevin Brazil, Jenny Ploeg, Monica Quinlan, Noori Akhtar-Danesh, Jean Lillie, Linda Boos, Margaret Denton, Jennifer Millen Plenderleith   +9 more
core  

Older adults’ suggestions to engage other older adults in health and healthcare: a qualitative study conducted in western Canada

Patient Preference and Adherence, 2019
Huey-Ming Tzeng,1 Udoka Okpalauwaekwe,2 Chang-Yi Yin3 1College of Nursing, University of Saskatchewan, Saskatoon, SK, Canada; 2Department of Academic Family Medicine, College of Medicine, University of Saskatchewan, Saskatoon, SK, Canada; 3Taiwan ...
Tzeng HM, Okpalauwaekwe U, Yin CY
doaj  

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Frailty in older people living in Africa: A systematic review of prevalence and associated factors

Archives of Gerontology and Geriatrics Plus
Background: Despite rapid population ageing in Africa, research on frailty in the region remains limited and fragmented. This systematic review aimed at summarising the available data to determine the prevalence of frailty in Africa.
Ayele Semachew Kasa, Shu-Chun Lee, Hui-Chen (Rita) Chang   +2 more
doaj   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Incident disability in older adults: prediction models based on two British prospective cohort studies

, 2014
Objective: to develop and validate a prediction model for incident locomotor disability after 7 years in older adults.Setting: prospective British cohort studies: British Women's Heart and Health Study (BWHHS) for development and the English Longitudinal
Bowling, A., Kumari, Meena, Prieto-Merino, David, Dale, C.E., Kumari, M., Casas, Juan P, Bowling, Ann, Prieto-Merino, D., Pablo, Perel, Nüesch, Eveline, Dale, Caroline E, Pablo, P., Casas, J.P., Ebrahim, S., Ebrahim, Shah, Nuesch, E.   +15 more
core   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Identifying leading anti-inflammatory dietary determinants of depression and loneliness in older adults

Brain, Behavior, & Immunity - Health
Objectives: The study aims to explore the association between anti-inflammatory dietary variables and prevalence of depression and loneliness in older adults.
Yujia Zhang, Eleonora Iob, Thamara Tapia Munoz   +2 more
doaj   +1 more source