Results 131 to 140 of about 9,063,075 (357)

Fatores contextuais associados ao diagnóstico tardio de HIV em pessoas com 50 anos ou mais no Brasil (2017–2022)

DST
Introdução: O envelhecimento populacional apresenta implicações na saúde para além de aspectos individuais. Pessoas com 50 anos ou mais podem apresentar menor percepção de risco, menor acesso a estratégias preventivas e maior vulnerabilidade estrutural ...
Denise Eliziana de Souza, Léa de Freitas Amaral, Christiano Barbosa da Silva, Fernanda Letícia dos Santos Ferreira   +3 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Global Disease Burden Estimates of Respiratory Syncytial Virus-Associated Acute Respiratory Infection in Older Adults in 2015: A Systematic Review and Meta-Analysis.

Journal of Infectious Diseases, 2019
Respiratory syncytial virus-associated acute respiratory infection (RSV-ARI) constitutes a substantial disease burden in older adults aged ≥65 years.
T. Shi, Angeline Denouel, A. K. Tietjen, I. Campbell, E. Moran, Xue Li, H. Campbell, C. Demont, B. Nyawanda, H. Chu, S. Stoszek, A. Krishnan, P. Openshaw, A. Falsey, H. Nair, H. Nair, H. Campbell, T. Shi, Shanshan Zhang, You Li, P. Openshaw, J. Wedzicha, A. Falsey, Mark Miller, P. Beutels, L. Bont, A. Pollard, Eva Molero, F. Martinón-Torres, T. Heikkinen, A. Meijer, T. Fischer, M. van den Berge, C. Giaquinto, R. Mikolajczyk, Judy Hackett, Bing Cai, C. Knirsch, A. Leach, S. Stoszek, Scott Gallichan, A. Kieffer, C. Demont, Angeline Denouel, A. Chéret, S. Gavart, J. Aerssens, Robert Fuentes, B. Rosen   +48 more
semanticscholar   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Cognition and arthritis in adults over 50: Evidence from CHARLS, HRS, and ELSA

Annals, Academy of Medicine, Singapore
Introduction: Arthritis and cognitive decline are significant health challenges in ageing populations, yet their association across diverse socioeconomic and cultural contexts remains insufficiently understood.
Litao Huo, Fei Wang, Yifan Niu, Jie Cui, Ying Jiang, Jialin Shi, Yongyu Hao, Jiaxu Wang, Shibo Huang, Lin Tan, Bo Gao   +10 more
doaj   +1 more source

Hypertension in older adults: Assessment, management, and challenges

Clinical Cardiology, 2019
Hypertension in older adults is related to adverse cardiovascular outcomes, such as heart failure, stroke, myocardial infarction, and death. The global burden of hypertension is increasing due to an aging population and increasing prevalence of obesity ...
E. Oliveros, Hena Patel, S. Kyung, S. Fugar, Alan B Goldberg, N. Madan, K. Williams   +6 more
semanticscholar   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Self-harm in older adults: Systematic review

, 2019
Background Self-harm is a major public health concern. Increasing ageing populations and high risk of suicide in later life highlight the importance of identification of the particular characteristics of self-harm in older adults.
Lisa Dikomitis, Opeyemi Babatunde, M. Isabela Troya, Kay Polidano, Carolyn A. Chew-Graham, Bernadette Bartlam, McCloskey, E.   +6 more
core   +1 more source

Promoting the empowerment and emancipation of community-dwelling older adults with chronic multimorbidity through a home visiting programme: a hermeneutical study

BMC Nursing
Introduction Nurse-led preventive home visiting programmes can improve health-related outcomes in community-dwelling older adults, but they have not proven to be cost-effective.
Iria Dobarrio-Sanz, Anabel Chica-Pérez, Olga María López-Entrambasaguas, José Manuel Martínez-Linares, José Granero-Molina, José Manuel Hernández-Padilla   +5 more
doaj   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source