Results 121 to 130 of about 9,063,075 (357)
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Experiences of in-home evaluation of independent living technologies for older adults
, 2009 Evaluating home-based independent living technologies for older adults is essential. Whilst older adults are a diverse group with a range of computing experiences, it is likely that many of this user group may have little experience with technology and ...
Bailey, Cathy, Dromey, Ben, Doyle, Julie
core
Vaccination in older adults with cancer and older cancer survivors
, 2021 Vaccination is one of the most effective means of preventing infections and should be widely promoted, especially in immunocompromised patients, such as older adults with cancer and older cancer survivors.
Negrete-Najar,Juan Pablo +7 more
core +1 more source
The human gut microbiome across the life course
FEBS Letters, EarlyView.Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero +4 more
wiley +1 more source
The Role of Coping Humour in the Physical and Mental Health of Older Adults [PDF]
Objectives - This study examined the associations among coping humor, other personal/social factors, and the health status of community-dwelling older adults. Method - Survey questionnaires were completed with 73 community dwelling older adults. Included
Elsa Marziali +2 more
core
Association between depressive symptoms and social support in a nationally representative sample of older adults (ELSI-Brasil) [PDF]
Brazilian Journal of PsychiatryObjective: To investigate the association between depressive symptoms and social support among a representative sample of the Brazilian population aged 50 years or older.
Beatriz Oliveira Carvalho +3 more
doaj +1 more source
Working memory revived in older adults by synchronizing rhythmic brain circuits
Nature Neuroscience, 2019 Understanding normal brain aging and developing methods to maintain or improve cognition in older adults are major goals of fundamental and translational neuroscience.
R. Reinhart, John A. Nguyen
semanticscholar +1 more source
The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome
FEBS Letters, EarlyView.This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley +1 more source
Describing Disability among High and Low Income Status Older Adults in Canada [PDF]
The purpose of this study was to determine the prevalence, types, and severity of disabilities, as well as the medical conditions that may have caused disabilities among non-institutionalized older adults by high and low income. Disabled individuals aged
Larry W. Chambers +4 more
core +2 more sources
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source