Results 111 to 120 of about 9,063,075 (357)

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Older adults' comprehension of speech as interactive domestic alarm system output: A field study

, 2003
Please contact the publisher for further reprinting or re-use.A rapidly ageing population has led to the development of Interactive Domestic Alarm Systems (IDASs) to assist older adults with independent living.
Lines, L, Hone, KS
core  

Low Vision Rehabilitation in Older Adults

Türk Oftalmoloji Dergisi, 2016
Objectives: To evaluate the diagnosis distribution, low vision rehabilitation methods and utilization of low vision rehabilitation in partially sighted persons over 65 years old.
Zuhal Özen Tunay, Aysun İdil, İkbal Seza Petriçli   +2 more
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Facilitating clinical application of a dimensional model for personality disorders across the entire adult lifespan: thresholds for dysfunction and a multi-method approach

Frontiers in Psychology
IntroductionThe classification of personality disorders (PDs) may be enhanced by dimensional models such as the Alternative Model for Personality Disorders (AMPD) and the ICD-11.
Morag Facon, Eva Dierckx, Eva Dierckx, Sebastiaan P. J. van Alphen, Sebastiaan P. J. van Alphen, Sebastiaan P. J. van Alphen, Selinay Surer, Gina Rossi   +7 more
doaj   +1 more source

Tuberculosis among older adults – time to take notice

International Journal of Infectious Diseases, 2015
Knowledge that older people are vulnerable to develop tuberculosis is rarely considered in developing country settings. According to 2010 Global Burden of Disease estimates, the majority of tuberculosis-related deaths occurred among people older than 50;
Joel Negin, Seye Abimbola, Ben J. Marais
doaj   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Barriers and facilitators to the use of clinical practice guidelines in osteoarthritis care: a qualitative study among German physiotherapists

BMJ Open
Objectives The objective of this study was to explore barriers and facilitators to the use of clinical practice guidelines (CPGs) in osteoarthritis (OA) care among German physiotherapists.Design Qualitative semistructured interviews were conducted with ...
Carolin Bahns, Lisa Happe, Christian Kopkow   +2 more
doaj   +1 more source

The Medical Costs of Fatal Falls and Fall Injuries among Older Adults

Journal of The American Geriatrics Society, 2018
To estimate medical expenditures attributable to older adult falls using a methodology that can be updated annually to track these expenditures over time.
Curtis Florence, Gwen Bergen, A. Atherly, E. Burns, J. Stevens, Cynthia Drake   +5 more
semanticscholar   +1 more source