Results 91 to 100 of about 2,390,893 (252)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Barriers and facilitators to the use of clinical practice guidelines in osteoarthritis care: a qualitative study among German physiotherapists

BMJ Open
Objectives The objective of this study was to explore barriers and facilitators to the use of clinical practice guidelines (CPGs) in osteoarthritis (OA) care among German physiotherapists.Design Qualitative semistructured interviews were conducted with ...
Carolin Bahns, Lisa Happe, Christian Kopkow   +2 more
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Bridging the gap in aging systems: health literacy and community health worker workforce innovation to address health-related social needs

Frontiers in Public Health
IntroductionOlder adults experience complex health and social challenges, including chronic disease, polypharmacy, caregiving demands, social isolation, and unmet health-related social needs (HRSN).
Teresa Wagner, Sarah Murphy, Saphina Achi   +2 more
doaj   +1 more source

Low Vision Rehabilitation in Older Adults

Türk Oftalmoloji Dergisi, 2016
Objectives: To evaluate the diagnosis distribution, low vision rehabilitation methods and utilization of low vision rehabilitation in partially sighted persons over 65 years old.
Zuhal Özen Tunay, Aysun İdil, İkbal Seza Petriçli   +2 more
doaj   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Describing Disability among High and Low Income Status Older Adults in Canada [PDF]

The purpose of this study was to determine the prevalence, types, and severity of disabilities, as well as the medical conditions that may have caused disabilities among non-institutionalized older adults by high and low income. Disabled individuals aged
Larry W. Chambers, Amiram Gafni, Parminder Raina, Micheline Wong, Margaret Denton   +4 more
core   +2 more sources

Association between depressive symptoms and social support in a nationally representative sample of older adults (ELSI-Brasil) [PDF]

Brazilian Journal of Psychiatry
Objective: To investigate the association between depressive symptoms and social support among a representative sample of the Brazilian population aged 50 years or older.
Beatriz Oliveira Carvalho, Érico Castro-Costa, Maria Fernanda Lima-Costa, Antônio Ignácio de Loyola Filho   +3 more
doaj   +1 more source

The Role of Coping Humour in the Physical and Mental Health of Older Adults [PDF]

Objectives - This study examined the associations among coping humor, other personal/social factors, and the health status of community-dwelling older adults. Method - Survey questionnaires were completed with 73 community dwelling older adults. Included
Elsa Marziali, Lynn McDonald, Peter Donahue   +2 more
core