Results 101 to 110 of about 2,390,893 (252)

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Fatores contextuais associados ao diagnóstico tardio de HIV em pessoas com 50 anos ou mais no Brasil (2017–2022)

DST
Introdução: O envelhecimento populacional apresenta implicações na saúde para além de aspectos individuais. Pessoas com 50 anos ou mais podem apresentar menor percepção de risco, menor acesso a estratégias preventivas e maior vulnerabilidade estrutural ...
Denise Eliziana de Souza, Léa de Freitas Amaral, Christiano Barbosa da Silva, Fernanda Letícia dos Santos Ferreira   +3 more
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Investigating User Authentication in the Context of Older Adults [PDF]

Knowledge-based authentication is almost ubiquitous due to low cost and relatively straightforward implementation. Despite its popularity, there are some well-known problems associated with knowledge-based authentication, such as the cognitive load of ...
Nicholson, James
core  

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Promoting the empowerment and emancipation of community-dwelling older adults with chronic multimorbidity through a home visiting programme: a hermeneutical study

BMC Nursing
Introduction Nurse-led preventive home visiting programmes can improve health-related outcomes in community-dwelling older adults, but they have not proven to be cost-effective.
Iria Dobarrio-Sanz, Anabel Chica-Pérez, Olga María López-Entrambasaguas, José Manuel Martínez-Linares, José Granero-Molina, José Manuel Hernández-Padilla   +5 more
doaj   +1 more source

Cognition and arthritis in adults over 50: Evidence from CHARLS, HRS, and ELSA

Annals, Academy of Medicine, Singapore
Introduction: Arthritis and cognitive decline are significant health challenges in ageing populations, yet their association across diverse socioeconomic and cultural contexts remains insufficiently understood.
Litao Huo, Fei Wang, Yifan Niu, Jie Cui, Ying Jiang, Jialin Shi, Yongyu Hao, Jiaxu Wang, Shibo Huang, Lin Tan, Bo Gao   +10 more
doaj   +1 more source