Results 201 to 210 of about 2,637,459 (312)

The Treatment of Older Patients with Parkinson's Disease. [PDF]

Dtsch Arztebl Int
Djukic M, Yoshida-Stiksrud E, Nau R.
europepmc   +1 more source

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

FEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida, Kazuya Kusama, Ayaka Horiuchi, Yu Kawaguchi, Atsuya Tsuru, Mikihiro Yoshie, Kazuhiro Tamura   +6 more
wiley   +1 more source

Prognostic role of the 2MACE score in older patients with atrial fibrillation. [PDF]

Intern Emerg Med
Armentaro G, Crudo G, Daidone M, Menichelli D, Bortoluzzi M, Pastura CA, Divino M, Severini G, Imbalzano E, Pignatelli P, Andreozzi F, Pastori D, Tuttolomondo A, Sciacqua A.   +13 more
europepmc   +1 more source

PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines

FEBS Open Bio, EarlyView.
Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart, Manon Van den Abbeel, Christoph Schifflers, Karim Bouhjar, Andrea Scarmelotto, Alexis Khelfi, Anne‐Catherine Wera, Carine Michiels   +7 more
wiley   +1 more source

Healthcare professionals' perspectives on prescribing DOACs to frail older patients; the DOAC-FRAIL questionnaire. [PDF]

BMC Geriatr
de Jong MJ, Brys ADH, Braeken D, Pisters R, Janssen DJA, Altintas S, Robben SHM, Nicolaï S, Eurlings C, Zwietering A, De Jonghe M, Vaes B, De Backer T, Grymonprez M, Joosten H, Ten Cate H, Winckers K, Magdelijns FJH.   +17 more
europepmc   +1 more source

Exon 7 splicing of ERα predicts poor prognosis and increases phenotypic heterogeneity in luminal a subtype breast cancer

FEBS Open Bio, EarlyView.
ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui, Taobo Hu, Thomson Christian Husein, Wai Hei Shek, Bingrong Chen, Depeng Wang, Shu Wang, Weichuan Yu, Xiaodan Fan, Mengping Long, Toyotaka Ishibashi   +10 more
wiley   +1 more source

Impact of Combined Anticoagulant and Antiplatelet Therapy in Older Patients With Atrial Fibrillation: ANAFIE Subanalysis. [PDF]

J Am Heart Assoc
Kamogawa N, Toyoda K, Yamaguchi T, Inoue H, Yamashita T, Suzuki S, Kobayashi H, Miwa K, Yoshimura S, Inoue M, Ihara M, Ago T, Koga M, ANAFIE investigators.   +13 more
europepmc   +1 more source

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source

Mortality and Causes of Death After Metabolic Bariatric Surgery in Older Patients. [PDF]

Obes Surg
Gerber P, Santoni G, von Euler-Chelpin M, H Kauppila J, Holmberg D.   +4 more
europepmc   +1 more source