Results 201 to 210 of about 928,236 (267)

Consensus Formation and Change are Enhanced by Neutrality

Advanced Science, EarlyView.
Neutral agents are shown to enhance both the formation and overturning of consensus in collective decision‐making. A general mathematical model and experiments with locusts and humans reveal that neutrality enables robust consensus via simple interactions and accelerates consensus change by reducing effective population size.
Andrei Sontag, Janina A. Hoffmann, Tim Rogers, Christian A. Yates   +3 more
wiley   +1 more source

The Relation Between Quality of Life, Functional Impairment and Nutritional Status in Older People. [PDF]

Healthcare (Basel)
Chelu GC, Nuță CR, Băjenaru OL, Băjenaru L, Prada GI.   +4 more
europepmc   +1 more source

Agnuside Stabilizes the Complex I Assembly Factor NDUFAF6 to Reinforce Mitochondrial Efficiency and Thermogenic Responsiveness

Advanced Science, EarlyView.
ABSTRACT Brown and beige adipocytes dissipate energy as heat, yet effective strategies to enhance their mitochondrial efficiency remain limited. Here, we identify Agnuside (AGN) as a selective stabilizer of the complex I assembly factor NDUFAF6. AGN directly binds cytosolic NDUFAF6, suppresses its ubiquitination, prolongs its half‐life, and facilitates
Qingwen Zhao, Li Xie, Qianzhuo Wang, Shuying Dai, Bei Li, Yingjuan Zhang, Zhe Sun, Yue Gao   +7 more
wiley   +1 more source

A study of medication safety in rural older people in Luzhou City. [PDF]

Front Public Health
Xu S, Gong P, Huang P, Liu L, Liu X, Liu T, Li J.   +6 more
europepmc   +1 more source

PRMT1‐Mediated LDHA Methylation Drives STAT3 Lactylation to Orchestrate Intestinal Inflammation and Tumorigenesis

Advanced Science, EarlyView.
This study identifies an immunometabolic axis wherein SAM‐driven PRMT1 methylates LDHA, enhancing its activity. The resultant lactate induces STAT3 K709 lactylation, which stabilizes an active conformation to promote STAT3 phosphorylation and IL‐10 expression.
Hui Wang, Mengyu Zhang, Weipeng Gong, Jiaxuan Wu, Junping Zhang, Wenxiu Zhang, Yue Liu, Kui Wang, Canhua Huang, Jun Zhou, Sijin Wu, Yan Li, Tianliang Li   +12 more
wiley   +1 more source

RNA Helicase DDX21 Controls CD4+ T Cell Proliferation and Promotes Inflammatory Bowel Disease via Translational Control

Advanced Science, EarlyView.
ABSTRACT Inflammatory bowel disease (IBD) is characterized by dysregulated T cell responses. RNA helicases, including DExD‐box helicase 21 (DDX21), are pivotal in RNA metabolism, but their role in T cell‐mediated pathology during IBD remains unclear. Here, we demonstrate that DDX21 expression in CD4+ T cells correlates with cell cycle and translation ...
Yujuan Zhang, Chen Kan, Xinhui Yang, Yajuan Hao, Xuemin Cai, Mei Yang, Qianqian Zhang, Zhengting Wang, Ning Jiang, Lei Wang, Hua‐Bing Li, Jing Zhou   +11 more
wiley   +1 more source

Development of a digitalised complex intervention to promote activity of older people in rural areas: study protocol of a feasibility study. [PDF]

Pilot Feasibility Stud
Beutner K, Lamprecht J, Roggendorf S, Aßmann P, Hübner G, Steckelberg A, Schmidt H.   +6 more
europepmc   +1 more source

Positive changes after a reablement program for older people in the Netherlands: a mixed-methods feasibility study. [PDF]

BMC Geriatr
Branderhorst-Pruijssers E, Metzelthin S, Mouchaers I, Satink T, Graff M.   +4 more
europepmc   +1 more source

Enabling health and maintaining independence for older people at home: the 'HomeHealth' Randomised Controlled Trial.

Health Technol Assess
Walters K, Frost R, Barrado-Martín Y, Kalwarowsky S, Marston L, Pan S, Avgerinou C, Goodman C, Clegg A, Gardner B, Hopkins J, Mahmood F, Gould RL, Elaswarapou R, Jowett C, Skelton DA, Drennan VM, Cooper C, Kharicha K, Logan P, Prescot M, Thornton G, Rookes T, Catchpole J, Hunter R.   +24 more
europepmc   +1 more source