Results 71 to 80 of about 7,025,930 (294)

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

A Low Psoas Muscle Index Was Associated With a Poorer Overall Survival in Patients Who Underwent Percutaneous Nephrostomy

Aging and Cancer, EarlyView.
In patients with malignant ureteral obstruction undergoing percutaneous nephrostomy, sarcopenia defined by a low psoas muscle index was independently associated with poor overall survival on multivariate Cox regression analysis, suggesting that preoperative assessment of psoas muscle index may aid prognostic stratification in this population.
Kota Shimokihara, Takashi Kawahara, Kazuhide Makiyama, Hiroji Uemura   +3 more
wiley   +1 more source

Establishing the core elements of a frailty at the front door model of care using a modified real-time Delphi technique

BMC Emergency Medicine, 2023
Background Innovations in models of care for older adults living with frailty presenting to the emergency department (ED) have become a key priority for clinicians, researchers and policymakers due to the deleterious outcomes older adults experience due ...
Íde O’Shaughnessy, Christine Fitzgerald, Aoife Whiston, Patrick Harnett, Helen Whitty, Des Mulligan, Marian Mullaney, Catherine Devaney, Deirdre Lang, Jennifer Hardimann, Brian Condon, Christina Hayes, Alison Holmes, Louise Barry, Claire McCormack, Megan Bounds, Katie Robinson, Margaret O’Connor, Damien Ryan, Denys Shchetkovsky, Fiona Steed, Leonora Carey, Emer Ahern, Rose Galvin   +23 more
doaj   +1 more source

The Role of Calcitonin Gene‐Related Peptide in High‐Altitude Headache: A Prospective Field Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective High‐altitude headache (HAH) is a common neurological condition associated with rapid ascent to high altitude. The pathophysiological mechanisms underlying HAH remain incompletely understood. Calcitonin gene‐related peptide (CGRP), a neuropeptide implicated in migraine pathophysiology, may play a key role in the pathophysiology of ...
Roman Schniepp, Ludwig Karrasch, Helena Breitenstein, Andreas Straube, Katharina Kamm   +4 more
wiley   +1 more source

Randomized crossover trial of a modified ketogenic diet in Alzheimer’s disease

Alzheimer’s Research & Therapy, 2021
Background Brain energy metabolism is impaired in Alzheimer’s disease (AD), which may be mitigated by a ketogenic diet. We conducted a randomized crossover trial to determine whether a 12-week modified ketogenic diet improved cognition, daily function ...
Matthew C. L. Phillips, Laura M. Deprez, Grace M. N. Mortimer, Deborah K. J. Murtagh, Stacey McCoy, Ruth Mylchreest, Linda J. Gilbertson, Karen M. Clark, Patricia V. Simpson, Eileen J. McManus, Jee-Eun Oh, Satish Yadavaraj, Vanessa M. King, Avinesh Pillai, Beatriz Romero-Ferrando, Martijn Brinkhuis, Bronwyn M. Copeland, Shah Samad, Shenyang Liao, Jan A. C. Schepel   +19 more
doaj   +1 more source

Health and functional status among older people with HIV/AIDS in Uganda [PDF]

, 2011
Background: In sub-Saharan Africa, little is known about the health and functional status of older people who either themselves are HIV infected or are affected by HIV and AIDS in the family.
Naidoo, Nirmala, Eugene Kinyanda, Janet Seeley, Somnath Chatterji, Kinyanda, Eugene, Naidoo Nirmala, Nirmala Naidoo, Chatterji, Somnath, Mugisha Joseph, Joseph Mugisha, Kinyanda Eugene, Nakubukwa, Susan, Boerma, Ties, Mugisha, Joseph, Scholten Francien, Kowal, Paul, Seeley, Janet, Kowal Paul, Francien Scholten, Chatterji Somnath, Heiner Grosskurth, Susan Nakubukwa, Ties Boerma, Scholten, Francien, Nakubukwa Susan, Grosskurth Heiner, Paul Kowal, Seeley Janet, Grosskurth, Heiner, Boerma Ties   +29 more
core   +2 more sources

Acute Kidney Injury After Mechanical Thrombectomy for Stroke in Patients With Pre‐Existing Renal Impairment

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives Acute kidney injury (AKI) is a common but often underrecognized complication in ischemic stroke patients undergoing mechanical thrombectomy, particularly among those with pre‐existing renal impairment. This study evaluated the incidence, risk factors, and clinical impact of AKI in this high‐risk population.
Michał Borończyk, Marcel Pilarek, Emilia Jaworska, Natalia Kardas, Oliwia Barnaś, Julia Woźniak, Iga Machała, Julia Węgrzynek‐Gallina, Joanna Siuda, Anna Hawrot‐Kawecka, Anetta Lasek‐Bal   +10 more
wiley   +1 more source

Influenza Vaccination Responses in Disabled Stroke Patients: A Single‐Center Prospective Observational Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective This study aimed to investigate the immunological response to influenza vaccination, the incidence and severity of influenza infection, and the side effects of the vaccination in patients with ischemic stroke. Methods This prospective observational study was conducted between 2023 and 2024 at Ramathibodi Hospital.
Achiraya Pakngao, Sureerat Suwatcharangoon, Pintip Ngamjanyapron, Kobporn Boonnak, Thanitta Suangtamai, Porpon Rotjanapan   +5 more
wiley   +1 more source

Dementia Assessment and Management Protocol for Doctors in Nepal

Journal of Nepal Medical Association, 2013
WHO Dementia Report published in 2012 highlighted the exponential rise of dementia in the elderly population worldwide, especially in low-and middle-income countries.
Arun Jha, Nidesh Sapkota
doaj   +3 more sources

Feasibility of the WHO Infection Prevention and Control Assessment Framework in long-term care facilities: a pilot study in the Netherlands

Antimicrobial Resistance and Infection Control
Background The World Health Organization’s Infection Prevention and Control Assessment Framework (IPCAF) is widely used to evaluate infection prevention and control (IPC) quality in hospitals, but IPC standards in long-term care facilities (LTCFs) are ...
K. Halonen, A. Haenen, M. Smalbrugge, L. W. van Buul, R. C. Wang, C. Schneeberger, D. W. Notermans, S. E. Geerlings, S. C. de Greeff   +8 more
doaj   +1 more source