Results 61 to 70 of about 7,025,930 (294)

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Risk of venous thrombosis and pulmonary embolism in older in-patients with mental illness: systematic review

BJPsych Bulletin
Aims and method Venous thromboembolism (VTE) is a fatal condition affecting older people. This study aims to identify specific risk factors for VTE in older psychiatric in-patients within mental hospital settings.
Damodar Chari, Tamara Chithiramohan, Ina Sawhney, Elizabeta B. Mukaetova-Ladinska, Lucy Beishon, Hari Subramaniam   +5 more
doaj   +1 more source

The influence of ACE inhibitors and ARBs on hospital length of stay and survival in people with COVID-19

International Journal of Cardiology: Heart & Vasculature, 2020
Objective: During the COVID-19 pandemic the continuation or cessation of angiotensin-converting enzyme inhibitors (ACEi) and angiotensin receptor blockers (ARBs) has been contentious.
Philip Braude, Ben Carter, Roxanna Short, Arturo Vilches-Moraga, Alessia Verduri, Lyndsay Pearce, Angeline Price, Terence J. Quinn, Michael Stechman, Jemima Collins, Eilidh Bruce, Alice Einarsson, Frances Rickard, Emma Mitchell, Mark Holloway, James Hesford, Fenella Barlow-Pay, Enrico Clini, Phyo Kyaw Myint, Susan Moug, Kathryn McCarthy, Jonathan Hewitt   +21 more
doaj   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

A qualitative focus group study on legal experts’ views regarding euthanasia requests based on an advance euthanasia directive

BMC Medical Ethics
Background The Dutch Euthanasia law permits euthanasia in patients with advanced dementia lacking decisional capacity based on advance euthanasia directives.
D. O. Coers, S. H. Scholten, M. E. de Boer, E. M. Sizoo, M. A. J. M. Buijsen, B. J. M. Frederiks, C. J. W. Leget, C. M. P. M. Hertogh   +7 more
doaj   +1 more source

Pathways and pitfalls: a qualitative study of student experiences in biomedical science education

FEBS Open Bio, EarlyView.
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell, Cassy Ross, Panagiota S. Filippou, Bruno Silvester Lopes, Dominic Gilchrist, Paul Dean, Kamar Ameen‐Ali, Tora K. Smulders‐Srinivasan, Ahmad A. Khundakar   +8 more
wiley   +1 more source

Wessex Acute Frailty Audit: applying quality improvement methodology to design and implement a regional frailty audit using a collaborative, multiprofessional approach

BMJ Open Quality, 2020
Introduction An acute hospital stay increases the risk of negative outcomes for those living with frailty. This paper describes the application of quality improvement methodology to design and implement a regional audit to gain an understanding of care ...
Teresa Corbett, Kathy Wallis, Cheryl Davies, Lucy Anne Lewis, Kerry Burrows, Claire Spice   +5 more
doaj   +1 more source

TRPML1 agonist ML‐SA5 attenuates pulmonary fibroblast activation by suppressing mTOR and restoring autophagic flux

FEBS Open Bio, EarlyView.
TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao, Xiaoting Kang, Lulu Meng, Shaoxuan Zhang, Qiujie Li, Jinyu Zhou, Mengyue Xue, Chu Li, Hua Zhu, Pengzhou Hang, Jing Zhao   +10 more
wiley   +1 more source

Home-based geriatric rehabilitation after inpatient rehabilitation: a redesign and feasibility study

BMC Geriatrics
Background There is a shift from inpatient to home-based geriatric rehabilitation (HBGR), and potential benefits are demonstrated. Previously, a theoretical HBGR model, version 1.0, has been developed, outlining its essential components.
Astrid D. Preitschopf, Margriet Pol, Bianca Buurman, Marije Holstege   +3 more
doaj   +1 more source

Delirium in older people [PDF]

BMJ, 2007
Few ill health situations are more degrading to people of any age than loss of reasoning, faculties, and personhood. These are the unpleasant consequences of delirium—a common condition affecting ill older people, particularly those with some degree of dementia. It is characterised by recent onset of fluctuating inattention and confusion, linked to one
John, Young, Sharon K, Inouye
openaire   +2 more sources