Results 191 to 200 of about 926,771 (267)

Genome‐Wide In Vivo RNAi Screening Identifies HOXD4 as a Tumor Metastasis Suppressor in Colorectal Cancer

Advanced Science, EarlyView.
Metastasis remains a major challenge in colorectal cancer. Using an in vivo shRNA screening system, this study identifies Homeobox D4 as a key metastasis suppressor. Reduced Homeobox D4 expression is associated with aggressive tumor features. Functional and mechanistic analyses show that it inhibits epithelial‐mesenchymal transition by repressing ...
Zhi‐hua Ye, Wen‐jing Luo, Lu Li, Wen‐di Shuai, Ling Zhou, You‐fa Duan, Xue Chen, Jun‐kai Zhang, Wenlin Huang, Ran‐yi Liu   +9 more
wiley   +1 more source

Australian clinical guideline for deprescribing in older people. [PDF]

Aust Prescr
europepmc   +1 more source

A study of medication safety in rural older people in Luzhou City. [PDF]

Front Public Health
Xu S, Gong P, Huang P, Liu L, Liu X, Liu T, Li J.   +6 more
europepmc   +1 more source

A Pollen‐Enhanced Bionic Mechanoreceptor Induced by Asymmetric Ionic Convection in Hydrogel for Sensory‐Augmented Prostheses

Advanced Science, EarlyView.
This work proposed a pollen‐enhanced bionic mechanoreceptor based on ionic convection. Leveraging the ion anchoring effect of the pollen particle, the output performance could be ∼12 times higher than the original state. By employing deep learning models as AI brains, the feasibility of a sensory‐augmented prosthesis consisting of a pollen‐enhanced ...
Zi Hao Guo, Jingyu Deng, Yanzhang Xu, Chenchen Zhou, Yangshi Shao, Xiong Pu, Munho Kim, Namjoon Cho   +7 more
wiley   +1 more source

Development of a digitalised complex intervention to promote activity of older people in rural areas: study protocol of a feasibility study. [PDF]

Pilot Feasibility Stud
Beutner K, Lamprecht J, Roggendorf S, Aßmann P, Hübner G, Steckelberg A, Schmidt H.   +6 more
europepmc   +1 more source

β‐Elemene Rescues Radiation‐Induced Enteritis by Orchestrating a Host‐Microbiome Circuit That Fuels Epigenetic DNA Repair

Advanced Science, EarlyView.
This study elucidates that β‐elemene promotes cellular uptake of L. gasseri‐derived lactate by enhancing the membrane translocation of MCT1 in a CD147‐dependent manner. Intracellular lactate, through the lactylation of RBBP4 at the K26 site, recruits EP300 to the promoter regions of downstream genes (POLD1/POLD3), catalyzing H3K27ac modification.
Jiancheng He, Jiapeng Bao, Shukang Deng, Weijie Zang, Haoming Yan, Zihao Zhao, Guangze Zhang, Ruiqing Liu, Junjie Chen, Yilin Hu, Wanjiang Xue   +10 more
wiley   +1 more source

Care Needs and Care Options for Frail Older People Living Alone in Italy: An Exploratory Mixed Study. [PDF]

Healthcare (Basel)
Melchiorre MG, Socci M, Lamura G, Quattrini S.   +3 more
europepmc   +1 more source

Positive changes after a reablement program for older people in the Netherlands: a mixed-methods feasibility study. [PDF]

BMC Geriatr
Branderhorst-Pruijssers E, Metzelthin S, Mouchaers I, Satink T, Graff M.   +4 more
europepmc   +1 more source