Results 91 to 100 of about 113,993 (287)

Genetic Variants in KLOTHO Associate With Cognitive Function in the Oldest Old Group [PDF]

, 2015
Decline in cognitive abilities is a major concern in aging individuals. A potential important factor for functioning of the central nervous system in late-life stages is the KLOTHO (KL) gene.
Christensen, Kaare, Christiansen, Lene, McGue, Matt, Mengel-From, Jonas, Nygaard, Marianne, Sørensen, Mette   +5 more
core   +2 more sources

Multimorbidity as specific disease combinations, an important predictor factor for mortality in octogenarians: the Octabaix study

Clinical Interventions in Aging, 2017
Assumpta Ferrer,1 Francesc Formiga,2,3 Héctor Sanz,4 Jesús Almeda,5,6 Glòria Padrós7 On behalf of the Octabaix Study Group 1Primary Healthcare Department, Centre ‘El Plà’, DAP Metropolitana Sud ICS ...
Ferrer A, Formiga F, Sanz H, Almeda J, Padrós G   +4 more
doaj  

Blood pressure and hypertension prevalence among oldest-old in China for 16 year: based on CLHLS

BMC Geriatrics, 2019
Background There were little national data on hypertension based on the oldest-old, and lack of information on chronological changes. This study aimed to describe trends of blood pressure (BP) levels and hypertension prevalence for the past 16 years ...
Jiajun Du, Guoning Zhu, Yanhong Yue, Miao Liu, Yao He   +4 more
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

The Amazing Old Nova Q Cygni: A Far Ultraviolet Synthetic Spectral Analysis

, 2011
Q Cygni (Nova Cygni 1876) is the third oldest old novae (after WY Sge and V841 Oph) with a long orbital period of 10.08 hours and spectroscopic peculiarities in the optical including the presence of variable wind outflow revealed by optical P Cygni ...
Bruch A., Craig Kolobow, Duerbeck H., Edward Sion, Kafka S., Selvelli P.   +5 more
core   +1 more source

Inflammatory and immunological markers and risk for mortality and cognitive impairment in a longitudinal study of older adults from the longevous project

Archives of Gerontology and Geriatrics Plus
Senescence of the immunological system is characterized by alterations in immune system cells associated with aging, often linked to cognitive disorders and mortality.Objective:To determine the prevalence of immunological changes, including immunological
M.R. Caldeira, C.M. Almada-Filho, M.C. Brunialti, R. Salomão, M.S. Cendoroglo   +4 more
doaj   +1 more source

Psychosocial Factors Associated with Longevity in the United States: Age Differences between the Old and Oldest-Old in the Health and Retirement Study

Journal of Aging Research, 2011
Recent growth in the number of adults surviving to advanced ages raises questions about the quality of life associated with increased longevity. Psychosocial factors have received relatively little attention in research on quality of life among the ...
Jennifer A. Ailshire, Eileen M. Crimmins
doaj   +1 more source

Biallelic Inactivation of NSD1 Associated With Carcinogenesis in Sotos Syndrome

Pediatric Blood &Cancer, EarlyView.
Nicholas A. Borja, Anuja Sule, Katie Ann McMullen, Aditi Dhir, Matthew D. Hall, Heather J. McCrea, Sakir Humayun Gultekin, Mustafa Tekin, Bradley Gampel   +8 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Analyzing the relationship between health insurance, health costs, and health care utilization [PDF]

Using data the Health and Retirement Survey and the Assets and Health Dynamics among the Oldest Old, this article provides an empirical analysis of the determinants of whether an individual purchases health insurance.
Eric French, Kirti Kamboj
core