Results 121 to 130 of about 113,993 (287)
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Survival differences among the oldest old in Sardinia: who, what, where, and why? [PDF]
A study of centenarians in Sardinia detected the existence of an area where the number of centenarians is higher than elsewhere, in particularly for men.
Graziella Caselli, Rosa Maria Lipsi
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Clinical Interventions in Aging, 2012 Åsa Enkvist, Henrik Ekström, Sölve ElmståhlDepartment of Health Sciences, Lund University, Malmö University Hospital, Malmö, SwedenObjectives: To describe change in functional ability in the oldest-old population during 3 ...
Enkvist Å +2 more
doaj
Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer
Molecular Oncology, EarlyView.PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta +10 more
wiley +1 more source
Successful aging Among the Oldest Old
, 2018 Vuosisatojen ajan ihmiset ja yhteiskunnat ovat tavoitelleet pidempää ja terveempää elämä ja parempaa elämän laatua. Nyt 21. vuosisadalla voimme todistaa vanhuusiän kuolleisuuden nopeaa laskua ja hyvin vanhan ikäryhmän ennennäkemätöntä kasvua. Elämän pidentyminen ei kuitenkaan välttämättä merkitse parempaa terveyttä ja elämän laatua.
openaire +3 more sources
BMC GeriatricsBackground Sleep and its architecture are affected and changing through the whole lifespan. We know main modifications of the macro-architecture with a shorter sleep, occurring earlier and being more fragmented.
Bastien Poirson +3 more
doaj +1 more source
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
Why is health treatment for the elderly less expensive than for the rest of the population? Health care rationing in Germany [PDF]
The consequences of population ageing for the health care system and health care costs may be less severe than is commonly assumed. Hospital discharge data from Germany’s largest health insurer (AOK) show that the care of patients during their last year ...
Hilke Brockmann
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Kidney function and cognitive decline in an oldest-old Chinese population
Clinical Interventions in Aging, 2017 Kunhao Bai,1,2,* Yujing Pan,3,* Fanghong Lu,4 Yingxin Zhao,4 Jinwei Wang,1,2 Luxia Zhang1,2 1Renal Division, Department of Medicine, Peking University First Hospital, Beijing, People’s Republic of China; 2Peking University Institute of Nephrology,
Bai K +5 more
doaj
Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source