Results 141 to 150 of about 113,993 (287)
Thirty-day mortality in the oldest old with spontaneous subarachnoid hemorrhage
World Neurosurgery: XObjective: Spontaneous subarachnoid hemorrhage (SAH) is a severe disease with a high mortality rate that frequently occurs in the elderly. People aged 80 years and over can be regarded as the oldest old and are a rapidly growing segment of the population.
Yu-Hua Huang, Tsung-Han Lee
doaj +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
NKCC1: A key regulator of glioblastoma progression
Molecular Oncology, EarlyView.Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen +5 more
wiley +1 more source
Enhancing the Quality of Data on Income: Recent Developments in Survey Methodology [PDF]
In this paper, we evaluate two survey innovations aimed at improving income measurement. These innovations are (1) integrating the question sequences for income and wealth which may elicit more accurate estimates of income from capital than has been true
F. Thomas Juster +2 more
core
Some Demographic Consequences of Revising the Definition of 'Old' to Reflect Future Changes in Life Table Probabilities [PDF]
Sixty-five has long been used to define the beginning of 'old age'. Yet it is clear that the definition is arbitrary, and with continuing reductions in mortality and morbidity rates it will become increasingly inappropriate as time passes.
Byron G. Spencer, Frank T. Denton
core +3 more sources
Clinical Interventions in AgingJun Tao,1,2 Xiaoyan Zhang,2 Niansong Wang,1 Dongsheng Cheng1 1Department of Nephrology, Shanghai Sixth People’s Hospital Affiliated to Shanghai JiaoTong University School of Medicine, Shanghai, People’s Republic of China; 2Department of Geriatrics ...
Tao J, Zhang X, Wang N, Cheng D
doaj
Overview of molecular signatures of senescence and associated resources: pros and cons
FEBS Open Bio, EarlyView.Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas +6 more
wiley +1 more source
DDX3X induces mesenchymal transition of endothelial cells by disrupting BMPR2 signaling
FEBS Open Bio, EarlyView.Elevated DDX3X expression led to downregulation of BMPR2, a key regulator of endothelial homeostasis and function. Our co‐immunoprecipitation assays further demonstrated a molecular interaction between DDX3X and BMPR2. Notably, DDX3X promoted lysosomal degradation of BMPR2, thereby impairing its downstream signaling and facilitating endothelial‐to ...
Yu Zhang +7 more
wiley +1 more source
The oldest-old in China – Authors' reply [PDF]
The Lancet, 2017 Zeng, Yi +4 more
openaire +3 more sources