Results 101 to 110 of about 92,881 (268)

Age-related changes in sleep spindle characteristics in individuals over 75 years of age: a retrospective and comparative study

BMC Geriatrics
Background Sleep and its architecture are affected and changing through the whole lifespan. We know main modifications of the macro-architecture with a shorter sleep, occurring earlier and being more fragmented.
Bastien Poirson, Pierre Vandel, Hubert Bourdin, Silvio Galli   +3 more
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Kidney function and cognitive decline in an oldest-old Chinese population

Clinical Interventions in Aging, 2017
Kunhao Bai,1,2,* Yujing Pan,3,* Fanghong Lu,4 Yingxin Zhao,4 Jinwei Wang,1,2 Luxia Zhang1,2 1Renal Division, Department of Medicine, Peking University First Hospital, Beijing, People’s Republic of China; 2Peking University Institute of Nephrology,
Bai K, Pan Y, Lu F, Zhao Y, Wang J, Zhang L   +5 more
doaj  

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Functioning and quality of life in Dutch oldest old with diverse levels of dependency

Patient Preference and Adherence, 2018
Riaan Botes,1 Karin M Vermeulen,1 Antonie M Gerber,2 Adelita V Ranchor,3 Erik Buskens11Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands; 2Department of Basic Medical Sciences (G25 ...
Botes R, Vermeulen KM, Gerber AM, Ranchor AV, Buskens E   +4 more
doaj  

Functional trajectories associated with acute illness and hospitalization in oldest old patients: Impact on mortality [PDF]

, 2022
Eva M. Gallego‐González, Jennifer Mayordomo‐Cava, María Teresa Vidán, Maria Isabel Valadés-Malagón, José Antonio Serra Rexach, Javier Ortiz-Alonso   +5 more
openalex   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Mortality statistics for the oldest-old

Demographic Research, 2000
The main purposes of this paper is to evaluate the quality of Canadian data among the oldest-old (80+) over the 1951-1995 period, and to compare estimations of Canadian probabilities of death based on the extinct generation method with those of other ...
doaj  

Polypharmacy in a Belgian cohort of community-dwelling oldest old: baseline observations and associated risk factors [PDF]

, 2015
Maarten Wauters, Monique Elseviers, Bert Vaes, Jean‐Marie Degryse, Olivia Dalleur, Robert Vander Stichele, Luc Van Bortel, Majda Azermai   +7 more
openalex   +1 more source

NKCC1: A key regulator of glioblastoma progression

Molecular Oncology, EarlyView.
Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen, Diana Freitag, Madlen Haase, Christian Senft, Falko Schwarz, Silke Keiner   +5 more
wiley   +1 more source