Results 91 to 100 of about 735,066 (303)
Statins for primary and secondary prevention in the oldest old : an overview of the existing evidence [PDF]
, 2012 Hypercholesterolemia, although a modifiable risk factor for cardiovascular disease, is still one of the leading causes of death among older people in western countries.
Petrovic, Mirko +2 more
core +1 more source
FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
Human longevity is associated with regular sleep patterns, maintenance of slow wave sleep, and favorable lipid profile [PDF]
, 2014 Some individuals are able to successfully reach very old ages, reflecting higher adaptation against age-associated effects. Sleep is one of the processes deeply affected by aging; however few studies evaluating sleep in long-lived individuals (aged over ...
Andersen, Monica Levy +6 more
core +2 more sources
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Clinical Interventions in Aging, 2017 Assumpta Ferrer,1 Francesc Formiga,2,3 Héctor Sanz,4 Jesús Almeda,5,6 Glòria Padrós7 On behalf of the Octabaix Study Group 1Primary Healthcare Department, Centre ‘El Plà’, DAP Metropolitana Sud ICS ...
Ferrer A +4 more
doaj
Blood pressure and hypertension prevalence among oldest-old in China for 16 year: based on CLHLS
BMC Geriatrics, 2019 Background There were little national data on hypertension based on the oldest-old, and lack of information on chronological changes. This study aimed to describe trends of blood pressure (BP) levels and hypertension prevalence for the past 16 years ...
Jiajun Du +4 more
doaj +1 more source
Some Demographic Consequences of Revising the Definition of 'Old' to Reflect Future Changes in Life Table Probabilities [PDF]
Sixty-five has long been used to define the beginning of 'old age'. Yet it is clear that the definition is arbitrary, and with continuing reductions in mortality and morbidity rates it will become increasingly inappropriate as time passes.
Byron G. Spencer, Frank T. Denton
core
Analysis of health and longevity in oldest-old population: a health capital approach [PDF]
, 2005 Using 2002 cross-sectional data and 1998, 2000, 2002 three waves of panel data from the Chinese Longitudinal Healthy Longevity Survey, we study health in oldest old population.
Zhao, Zhong
core
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Archives of Gerontology and Geriatrics PlusSenescence of the immunological system is characterized by alterations in immune system cells associated with aging, often linked to cognitive disorders and mortality.Objective:To determine the prevalence of immunological changes, including immunological
M.R. Caldeira +4 more
doaj +1 more source