Results 101 to 110 of about 735,066 (303)

Psychosocial Factors Associated with Longevity in the United States: Age Differences between the Old and Oldest-Old in the Health and Retirement Study

Journal of Aging Research, 2011
Recent growth in the number of adults surviving to advanced ages raises questions about the quality of life associated with increased longevity. Psychosocial factors have received relatively little attention in research on quality of life among the ...
Jennifer A. Ailshire, Eileen M. Crimmins
doaj   +1 more source

Fetal Brain Tumor Harboring a Unique ROCK1::BRAF Fusion

Pediatric Blood &Cancer, EarlyView.
Marllon Cindra Sant'Ana, Mariana Maschietto, Daniela Paz Leal, Ricardo de Santos de Oliveira, Mayara Ferreira Euzébio, Antonio Carlos dos Santos, Luciano Neder, Carlos Alberto Scrideli, Elvis Terci Valera   +8 more
wiley   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Mortality and Longevity Projections for the Oldest-Old in Portugal [PDF]

, 2008
The mortality decline observed in developed countries over the last decades significantly increased the number of those surviving up to older ages. Mortality improvements are naturally viewed as a positive change for individuals and as a substantial ...
Bravo, Jorge, Coelho, Edviges, Magalhães, Maria   +2 more
core  

The MACHO Project 9 Million Star Color-Magnitude Diagram of the Large Magellanic Cloud [PDF]

, 2000
We present a 9 million star color-magnitude diagram (9M CMD) of the LMC bar. The 9M CMD reveals a complex superposition of different age and metallicity stellar populations, with important stellar evolutionary phases occurring over 3 orders of magnitude ...
A. B. Tomaney, A. Basu, A. C. Becker, A. J. Drake, B. A. Peterson, Becker S. A., Bertelli G., Bertelli G., Bessell M. S., Bono G., C. A. Nelson, C. Alcock, C. W. Stubbs, Catelan M., Corsi C. E., D. L. Welch, D. Minniti, D. P. Bennett, D. R. Alves, Elson R. A. W., Fagotto F., Fall S. M., Ferraro F., Guarnieri M. D., Hatzidimitriou D., Hoppner W., Jurcsik J., K. C. Freeman, K. Griest, K. H. Cook, L. King, Langer N., Lattanzio J. C., Lauterborn D., Lloyd Evans T., M. Geha, M. J. Lehner, M. R. Pratt, Maeder A., Marigo P., Ng Y. K., Ojha D. K., P. J. Quinn, P. Popowski, Pike C. D., R. A. Allsman, Reid N., Reid N., S. L. Marshall, Salaris M., Saviane I., Schaerer D., Schroder K.-P., Stothers R. B., T. S. Axelrod, T. Vandehei, Tifft W. G., W. Sutherland, Yoshii Y.   +58 more
core   +2 more sources

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Social Capital and Health in the Oldest Old

International Journal of Ageing and Later Life, 2006
The aim of this study was to measure social capital in the oldest old, and its association with different dimensions of health. The Umeå 85+ study is a cross-sectional study of 253 people, aged 85 years, 90 years and 95 years or older.
Fredrica Nyqvist, Janna Gustavsson, Yngve Gustafsson   +2 more
doaj   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Survival differences among the oldest old in Sardinia: who, what, where, and why? [PDF]

A study of centenarians in Sardinia detected the existence of an area where the number of centenarians is higher than elsewhere, in particularly for men.
Graziella Caselli, Rosa Maria Lipsi
core  

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source